Adrenergic receptor alpha-2
α and β adrenoceptors.
- Measurements
- 3
- Compounds
- 3
- Binding constants
- 2
- Median pX
- 4.91
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
No single gene answers to Adrenergic receptor alpha-2. Names like this one are families or unsubtyped preparations — a measurement made against whatever receptors a tissue carried, before or without resolving which subtype bound the compound. A family has no one accession, and picking a member to stand for it would invent a precision the assay never had: asked for “Muscarinic acetylcholine receptor” UniProt returns CHRM1, and that answer is wrong.
Resolver said no gene lists this target name as a synonym — recorded by tools/fetch_expression.py, not written here.
III · Ranking
Compounds by strongest binding constant
One bar per compound: its strongest Ki or Kd at this target, expressed as pX. Compounds measured here only by a functional assay do not appear — they are in the table below.
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Equilibrium binding constants 2
Ki and Kd — a concentration at equilibrium. Directly comparable across rows at the same target.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Adrenergic receptor alpha-2 | Adrenergic receptors | Ki | 7,830 | 5.11 | Rattus norvegicus | CHEMBL648713 |
| Adrenergic receptor alpha-2 | Adrenergic receptors | Ki | 19,000 | 4.72 | Rattus norvegicus | CHEMBL648713 |
Functional readouts 1
IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Adrenergic receptor alpha-2 | Adrenergic receptors | IC50 | 514 | 6.29 | Rattus norvegicus | CHEMBL647559 |