Adenosine receptor A2b
A1, A2A, A2B, A3.
- Measurements
- 3
- Compounds
- 1
- Binding constants
- 1
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
Adenosine receptor A2b
Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase
Quoted from UniProt’s FUNCTION annotation for P29275 (reviewed).
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
Where it sits in the cell
- Plasma membrane
- Vesiclesadditional
- Primary cilium tipadditional
Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.
UniProt, curated Cell membrane
Expression by cell type
Single cell type RNA, the 9 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Basal keratinocytes81.9 nCPM
- Retinal pigment epithelial cells59.7 nCPM
- Suprabasal keratinocytes57.3 nCPM
- Esophageal basal cells47.4 nCPM
- Conjunctival goblet cells45.6 nCPM
- Bergmann glia41.6 nCPM
- Respiratory secretory cells34.5 nCPM
- Urothelial cells33.5 nCPM
- Respiratory basal cells30.1 nCPM
Expression by tissue
The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.
- urinary bladder15.6 nTPM
- brain12.5 nTPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Equilibrium binding constants 1
Ki and Kd — a concentration at equilibrium. Directly comparable across rows at the same target.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Adenosine receptor A2b | Adenosine receptors | Ki | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5739263 |
Other measurements 2
Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Adenosine receptor A2b | Adenosine receptors | kon | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5739263 |
| Adenosine receptor A2b | Adenosine receptors | k_off | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5739263 |