3',5'-cyclic-AMP phosphodiesterase 4D
Named enzymes, including the metabolising cytochromes and the monoamine oxidases.
- Measurements
- 9
- Compounds
- 9
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
3',5'-cyclic-AMP phosphodiesterase 4D
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes
Quoted from UniProt’s FUNCTION annotation for Q08499 (reviewed).
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
Where it sits in the cell
- Plasma membrane
- Cytosol
- Nucleoplasmadditional
- Nuclear membraneadditional
- Primary ciliumadditional
Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.
UniProt, curated Apical cell membrane · Cytoplasm · Membrane · Cytoplasm, cytoskeleton · Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Expression by cell type
Single cell type RNA, the 8 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Renal connecting tubule cells10,730.8 nCPM
- Myonuclei8,670.8 nCPM
- Prostatic glandular cells7,016.6 nCPM
- Neutrophil progenitors5,306.2 nCPM
- Salivary acinar cells5,022.2 nCPM
- Renal collecting duct intercalated cells4,569.2 nCPM
- Renal collecting duct principal cells4,333.3 nCPM
- Proximal tubule cells4,114.6 nCPM
Expression by tissue
The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.
- bone marrow70.7 nTPM
- skeletal muscle63.5 nTPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Functional readouts 9
IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| 3',5'-cyclic-AMP phosphodiesterase 4D | Enzymes | AC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5291858 |
| 3',5'-cyclic-AMP phosphodiesterase 4D | Enzymes | AC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5291858 |
| 3',5'-cyclic-AMP phosphodiesterase 4D | Enzymes | AC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5291858 |
| 3',5'-cyclic-AMP phosphodiesterase 4D | Enzymes | AC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5291858 |
| 3',5'-cyclic-AMP phosphodiesterase 4D | Enzymes | AC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5291858 |
| 3',5'-cyclic-AMP phosphodiesterase 4D | Enzymes | AC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5291858 |
| 3',5'-cyclic-AMP phosphodiesterase 4D | Enzymes | AC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5291858 |
| 3',5'-cyclic-AMP phosphodiesterase 4D | Enzymes | AC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5291858 |
| 3',5'-cyclic-AMP phosphodiesterase 4D | Enzymes | AC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5291858 |