UCD0162
PubChem records this structure as 1-methyl-1,2,5,6-tetrahydropyridine-3-(N,N-diethylcarboxamide).
N,N-diethyl-1-methyl-3,6-dihydro-2H-pyridine-5-carboxamide
- PubChem CID
- 3084450
- ChEMBL
- — not recorded in the archive
- Measurements
- 0
- InChIKey
- QELRLWHVJBVJOI-UHFFFAOYSA-N
Admitted on a publication
This compound is in the archive because a named paper characterized it. Basargin, Domokosa, Hennessey et al., Proceedings of the National Academy of Sciences 2026 prints it as UCD0162 (PMID 42709856). It reports Ki at psychLight2 (Table S1, Fig. 2A) and EC50 and Emax of Gq activation at 5-HT2A, 5-HT2B and 5-HT2C (Table S2, Figs. 3-5) — every one of which the paper records as ND, meaning it did not reach 75% inhibition or 30% activation at 10 uM. Also head-twitch dose-response in mice at 0.1, 1 and 10 mg/kg (Fig. 7B), which it did not induce. The Discussion states the monocyclic ergolog 'was completely inactive'.
ChEMBL holds no molecule whose InChIKey skeleton matches QELRLWHVJBVJOI, so it holds no measurement for this compound and cannot be its source. This record gains no measurement row from the paper either, because every readout the paper reports for it is ND. That is the finding, not a gap: a compound the archive holds, whose dossier says a named 2026 paper looked for activity at three serotonin receptors and found none it could quantify, is worth more than the archive's silence about it.
Identity The SI names the freebase 'N,N-diethyl-1-methyl-1,2,5,6-tetrahydropyridine-3-carboxamide' (Experimental Procedures for the Synthesis of UCD0162, p. S52), which agrees with the article's two-step route from N,N-diethylnicotinamide and its statement that the olefin sits in conjugation with the amide. PubChem CID 3084450 lists 'N,N-Diethyl-1-methyl-1,2,5,6-tetrahydropyridine-3-carboxamide' verbatim, differing only in the capitalization of 'Diethyl', with the CAS index form '3-Pyridinecarboxamide, N,N-diethyl-1,2,5,6-tetrahydro-1-methyl-' and CAS 26070-52-0; formula C11H20N2O. The mapping has a second, independent confirmation: the article's ref. 28 is Christian, McClain, Morin and Benington, Experientia 31:910-911 (1975), whose title is 'Blockage of LSD binding at its high affinity site on synaptosomal membranes by 1-methyl-1,2,5,6-tetrahydropyridine-N,N-diethylcarboxamide' — and PubChem's own title for CID 3084450 is '1-Methyl-1,2,5,6-tetrahydropyridine-3-(N,N-diethylcarboxamide)'. The 1975 paper, the 2026 paper and the PubChem record are all naming one molecule. The paper's material is the hydrochloride and this record is the free base; the molecule is achiral.
Read Two files, both read in full. The article as published (PNAS 2026;123(38):e2603412123, open access under CC BY): Significance, abstract, Introduction, all of Results, Discussion, Methods, the captions of Figs. 1-8, and the reference list. And the Supporting Information (Appendix 01, pnas.2603412123.sapp.pdf, 144 pp., retrieved from PNAS on 2026-09-09): the synthetic schemes S1-S9 and S12, the Experimental Procedures section carrying the systematic name, salt form, NMR, LC-MS, HRMS, IR and UHPLC purity for every ergolog, Tables S1-S5, and the pharmacology methods 'Radioligand Binding Assays', '5-HT2 Gq dissociation BRET Assays' and 'beta-Arrestin2 Recruitment BRET Assays'. The SI is what fixes each of the paper's compound codes to a molecule, and without it none of this would be admissible.
I · Summary
What is known
Published passages, each quoted whole and attributed to the database that published it. Two blocks are written here rather than quoted, and both say so where they stand: the synthesized summary at the top, which may draw only on the passages beneath it, and the history note, which cites the works it came from. Every claim in either carries a marker to its source.
— No descriptive record. PubChem holds no attributed passage about UCD0162 under any heading this site reads, and ChEMBL curates no mechanism for it. That is the common case for the research chemicals in this archive: they have structures and binding measurements, and nobody has written a monograph. The measurements are still on the plates that follow.
History, discovery and cultural use
— Not in this archive. PubChem, ChEMBL and the Human Protein Atlas publish pharmacology, regulation and toxicology, and none of them publishes a heading for when UCD0162 was first made, by whom, or how it has been used. That is a gap in the databases this site reads and not a gap in the literature — the history of these compounds is written, at length and under peer review, in the works below. This site does not summarize them; it says where they are. Where a published passage above happens to touch origin or traditional use, it appears inside the entry that carries it.
Histories of this field
Scholarship on psychedelics generally, not on UCD0162 specifically. Whether any of these treats this compound is a question for the book, not for this page.
Mescaline: A Global History of the First Psychedelic
Traces mescaline and the peyote and San Pedro cacti from pre-Columbian ritual use through nineteenth-century chemistry to twentieth-century psychiatry and the counterculture.
Jay M. Mescaline: A Global History of the First Psychedelic. Yale University Press, New Haven and London; 2019. ISBN 9780300231076.
Expanding Mindscapes: A Global History of Psychedelicsopen access
Essays on the international and cross-cultural history of psychedelic science, deliberately decentring the standard North American and European account.
Dyck E, Elcock C, editors. Expanding Mindscapes: A Global History of Psychedelics. The MIT Press, Cambridge MA; 2023. ISBN 9780262546935 (paper), 9780262376891 (open access). doi:10.7551/mitpress/14417.001.0001.
Plants of the Gods: Their Sacred, Healing, and Hallucinogenic Powers
Botany, ethnography and chemistry of the principal hallucinogenic plants, by the founder of modern ethnobotany and the chemist who first synthesized LSD.
Schultes RE, Hofmann A, Rätsch C. Plants of the Gods: Their Sacred, Healing, and Hallucinogenic Powers. 2nd ed. Healing Arts Press, Rochester VT; 2001. ISBN 9780892819799.
Psychonauts: Drugs and the Making of the Modern Mind
The tradition of scientific self-experimentation with psychoactive drugs, and its part in the emergence of psychology and of modernism.
Jay M. Psychonauts: Drugs and the Making of the Modern Mind. Yale University Press, New Haven; 2023. ISBN 9780300257946.
Ancient Psychoactive Substances
Archaeological and bioarchaeological evidence for psychoactive plant use across the ancient world.
Fitzpatrick SM, editor. Ancient Psychoactive Substances. University Press of Florida, Gainesville; 2018. ISBN 9780813056708.
A chapter tracing psychedelic and entactogen research from earlier ritual use through the mid-century research period to current clinical trials.
Stroud C, Posey Norris SM, Matney C, editors. History and Current Status of Psychedelics and Entactogens for the Treatment of Psychiatric Disorders. In: Exploring Psychedelics and Entactogens as Treatments for Psychiatric Disorders: Proceedings of a Workshop. National Academies Press, Washington DC; 2022. NBK587225.
Workshop proceedings record what participants said; they are not a consensus statement of the National Academies.
Peer-reviewed review covering the isolation, synthesis, pharmacology and ritual use of peyote and mescaline.
Dinis-Oliveira RJ, Pereira CL, da Silva DD. Pharmacokinetic and Pharmacodynamic Aspects of Peyote and Mescaline: Clinical and Forensic Repercussions. Current Molecular Pharmacology 12(3):184–194; 2019. doi:10.2174/1874467211666181010154139.
Institutional archives
- Heffter Research Institute Funds and coordinates clinical research on psilocybin, and keeps records of the studies it has supported since 1993. Sponsors the research it archives.
- Multidisciplinary Association for Psychedelic Studies (MAPS) Sponsors clinical research, chiefly on MDMA-assisted therapy, and publishes an archive of historical and contemporary documents. A sponsor and an advocacy organization, not a disinterested archive; its clinical programme has a commercial arm.
The rest of this dossier
- Toxicology — nothing published for UCD0162. An absent record is an absence of study, not evidence of safety.
Passages via PubChem descriptive sections, aggregating DrugBank, LiverTox, FDA, DEA, HSDB, EPA. Each is quoted whole and attributed to the database that published it. The only prose written here about UCD0162 is the history note, which says so on its face and carries a reference for every claim in it.
II · Identity
Structure and descriptors
Descriptors are computed here with RDKit from the structure PubChem returns — not from the archive's stored copy, so an edited local structure cannot reach this table.
- Formula
- C11H20N2OR
- Molecular weight
- 196.29g/molR
- Exact mass
- 196.1576DaR
- cLogP
- 1.12R
- TPSA
- 23.6ŲR
- H-bond donors
- 0R
- H-bond acceptors
- 2R
- Rotatable bonds
- 3R
- Aromatic rings
- 0R
- Heavy atoms
- 14R
- Fraction sp³
- 0.727R
- Formal charge
- 0R
Computed with RDKit 2025.09.2 from the SMILES returned by PubChem. Audit run 26/09/2026.
III · Behavior
Behavioral summary
Class, mechanism, and the duration of acute effects — each quoted from the record or trial that publishes it. Duration of effects and plasma half-life are shown separately, because they are different quantities and diverge by a factor of three or four.
Classification
MeSH indexes no pharmacological class for this compound.
Duration of acute subjective effects
—
No controlled human trial reporting a duration for this compound is cited here. The archive holds no other record of one either. A duration is not inferred from a chemical relative.
Plasma elimination half-life
How fast the body clears the drug — not how long the effects last. The two diverge sharply: LSD is cleared with a half-life of about 2.6 h while its subjective effects run 8–12 h.
No half-life is published for this compound in the sources this site reads.
Primary pharmacological drivers
ChEMBL holds no curated mechanism-of-action record for this compound. The measured affinities below are the evidence this archive has for what it binds.
Nothing about this compound’s pharmacology is published with a citation in the sources this site reads. The measured binding data below is what the archive can show.
IV · Clinical
Clinical description
Where this compound's substance class sits in ICD-11 and DSM-5-TR, and how much of the recorded literature speaks to each domain of a mental status examination.
No diagnostic chapter is shown for this compound. Either PubChem records no MeSH pharmacological class for it, or the class it records is not one of the substance classes ICD-11 gives a chapter to. Inferring a chapter from the compound’s name or its binding profile would be a diagnosis this archive is in no position to make.
How much has been written about each domain
The clinical domains, and how many of the records this archive holds for this compound say something under each. What the terms mean, and the word list behind every spoke, are set out in the method.
None of the 0 records this archive holds for this compound uses a term from any of the clinical domains. That is a statement about the literature recorded here, not about the compound.
VI · Profile
Affinity rosette
No measurement for UCD0162 converts to an affinity at a molecular target, so there is no rosette to draw. This is an absence of data, not a finding about the compound.
VII · Toxicology
Toxicological profile
What has been measured, and what has been published — kept apart, and neither scored. There is no risk rating on this page; the archive once carried one, identical for every compound, produced by a stub.
Measured in this archive
Assays that bear on toxicity, drawn from the same ChEMBL records as everything else on this page. They are measurements of what a compound binds or does to cells — not verdicts about what it does to a person.
No hERG, cytochrome, cytotoxicity or transport measurement exists for UCD0162 in this archive.
Published toxicology
— None. The toxicology databases this site reads — HSDB, RTECS and LiverTox, by way of PubChem — hold no record for UCD0162. They index compounds that have been studied for decades, so most of this archive has no entry. An absent record is an absence of study, not evidence of safety.
Published passages via PubChem toxicology sections, aggregating Hazardous Substances Data Bank (HSDB), RTECS, LiverTox. No figure on this page is scored, ranked or combined into a risk level.
VIII · Evidence
Every measurement
One row per published value. The identifier in the last column resolves to the ChEMBL assay record it was read from.
No bioactivity measurement is recorded for this compound in the archive.
- P
- PubChem
- C
- ChEMBL
- R
- Computed here with RDKit
- D
- Derived here from the stored measurement
IX · Trials
Registered clinical trials
Studies filed with ClinicalTrials.gov that name this compound as an intervention. A registered trial is a protocol, not a result — status and enrollment are printed beside every row, and withdrawn studies are counted rather than hidden.
— No registered study names UCD0162 as an intervention. That is an absence of registered research, not evidence about the compound. Most of this archive has never been the subject of a registered trial.
Records from ClinicalTrials.gov (U.S. National Library of Medicine, NIH), API v2. A study is listed against a compound only when a verified name for that compound appears as a whole word in one of the study's own intervention names. A short code must appear as written, and a name the registry uses for something else (Aleph, a vaccine maker) is not matched. Title matches are not accepted. The matched name and the intervention text it matched are shown with every row.
Searched as UCD0162 · N,N-diethyl-1-methyl-1,2,5,6-tetrahydropyridine-3-carboxamide · 1-Methyl-1,2,5,6-tetrahydropyridine-3-(N,N-diethylcarboxamide). Run this search at the registry.
A registered trial is a protocol somebody filed with the registry. It is not a result, and nothing on this plate says whether UCD0162 worked.
X · Legal
Controlled-substance status
United States federal scheduling, read from the DEA records this archive holds. Not legal advice, and an absent record is not a finding that a compound is uncontrolled.
An absent DEA record is not a finding that UCD0162 is legal. It means this archive holds no DEA passage for it. The Controlled Substances Analogue Enforcement Act reaches substances that appear on no schedule by name, and many compounds here are ring-substituted analogues of scheduled drugs. Nothing on this plate should be read as saying a compound may lawfully be made, held or supplied.
United States federal status only. State law differs, and so does the law of every other country — none of it is represented here. Scheduling changes, and this reflects the DEA records held by PubChem descriptive sections when the monograph was last harvested, not necessarily today. This is a record of what a database publishes, not legal advice.
XI · Literature
Sources behind this dossier
The papers this compound's values were read from, ranked by what each contributed. Not a review of the field.
No reference is recorded against any value for this compound. Its measurements come from ChEMBL assay records that carry an assay identifier but no publication, so there is no paper to cite here — an absence in the upstream record, not a judgment about the evidence. The assay identifiers in Every measurement resolve to the records the values were read from.