U-251
Phenotypic screens. A value here is a cellular response, not a binding affinity. Values below are reported as measured; because this is not a molecular target, they are not treated as affinities anywhere on this site.
- Measurements
- 5
- Compounds
- 4
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
U-251 has no protein record here. A name resolves when ChEMBL’s own target record gives an accession, when the name appears verbatim in a gene’s synonym list, or when it matches a UniProt protein name exactly. Guessing from a name that merely looks like a receptor is how a histone gene ends up filed as an adrenoceptor.
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Functional readouts 1
IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| U-251 | Cell lines | IC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL2321024 |
Other measurements 4
Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| U-251 | Cell lines | GI50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1964047 |
| U-251 | Cell lines | GI50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1964047 |
| U-251 | Cell lines | GI50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1964047 |
| U-251 | Cell lines | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL6118151 |