Thymidine phosphorylase
Matched no rule. Shown as-is rather than assigned a class by guesswork. Values below are reported as measured; because this is not a molecular target, they are not treated as affinities anywhere on this site.
- Measurements
- 2
- Compounds
- 1
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
Thymidine phosphorylase
May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro
Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
Quoted from UniProt’s FUNCTION annotation for P19971 (reviewed).
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
Where it sits in the cell
- Nuclear bodies
- Golgi apparatus
- Cytosoladditional
Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.
Expression by cell type
Single cell type RNA, the 7 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- monocytes586.6 nCPM
- Neutrophils409.7 nCPM
- Extravillous trophoblasts378 nCPM
- cDC355.1 nCPM
- Macrophages281 nCPM
- Esophageal suprabasal cells240.4 nCPM
- Esophageal apical cells220.7 nCPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Other measurements 2
Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Thymidine phosphorylase | Unclassified | Activity | — no normalized value | — value does not convert to pX | Escherichia coli K-12 | CHEMBL971198 |
| Thymidine phosphorylase | Unclassified | Activity | — no normalized value | — value does not convert to pX | Escherichia coli K-12 | CHEMBL971204 |