Rap guanine nucleotide exchange factor 3
Matched no rule. Shown as-is rather than assigned a class by guesswork. Values below are reported as measured; because this is not a molecular target, they are not treated as affinities anywhere on this site.
- Measurements
- 1
- Compounds
- 1
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
Rap guanine nucleotide exchange factor 3
Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin
Quoted from UniProt’s FUNCTION annotation for O95398 (reviewed).
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
Where it sits in the cell
- Cytosol
- Endoplasmic reticulumadditional
Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.
UniProt, curated Endomembrane system
Expression by cell type
Single cell type RNA, the 10 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Podocytes190 nCPM
- Astrocytes134.1 nCPM
- Renal collecting duct principal cells114.2 nCPM
- Proximal tubule cells103.1 nCPM
- Loop of henle epithelial cells102.3 nCPM
- Renal connecting tubule cells91.9 nCPM
- Vascular endothelial cells85.6 nCPM
- Renal collecting duct intercalated cells62 nCPM
- Oligodendrocytes53.3 nCPM
- Papillary tip epithelial cells48.9 nCPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Functional readouts 1
IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Rap guanine nucleotide exchange factor 3 | Unclassified | Potency | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL3215079 |