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PsychedeliaDokholyan Laboratory
TargetUnclassified

Prothrombin

Matched no rule. Shown as-is rather than assigned a class by guesswork. Values below are reported as measured; because this is not a molecular target, they are not treated as affinities anywhere on this site.

Measurements
6
Compounds
6
Binding constants
0
Median pX
—

I · Identity

What this target is

Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.

Protein

THRB_HUMANF2Homo sapiens

Prothrombin

Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. Activates coagulation factor XI (F11); activation is promoted by the contact with negatively charged surfaces2019570,21976677. Triggers the production of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL8/CXCL8, in endothelial cells30568593,9780208

Quoted from UniProt’s FUNCTION annotation for P00734 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

PartnerCombinedExperimentDatabaseText mining
FGA0.9990.9660.9000.886
F50.9990.9260.9000.886
SERPINC10.9990.9770.9000.980
FGB0.9990.9000.9000.836
FGG0.9990.9000.9000.821
SERPIND10.9990.9460.9000.865
F100.9990.9300.7500.972
THBD0.9990.9670.9000.927
F2R0.9980.9460.9000.793
F30.9960.0000.5400.993

Where it sits in the cell

UniProt, curated Secreted, extracellular space

Expression by cell type

Single cell type RNA, the 1 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.

  • Hepatocytes1,119 nCPM

Expression by tissue

The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.

  • liver1,138.4 nTPM

II · Anatomy

Where the gene is transcribed

The same two atlases the compound plates use, asked about this gene alone. Brain on the left, peripheral and autonomic tissues on the right.

Brain

cerebral cortex — 0.1 nTPM, from F2cerebellum — 0.9 nTPM, from F2hippocampal formation — no resolved target expressed hereamygdala — no resolved target expressed herehypothalamus — 0.1 nTPM, from F2thalamus — no resolved target expressed herebasal ganglia — 0.2 nTPM, from F2medulla oblongata — no resolved target expressed here

basal ganglia: drawn as the caudate nucleus, putamen and globus pallidus.

Measured but not drawn — this anatomogram has no outline for them: pituitary gland 0.1.

Body

heart — 0.1 nTPM, from F2smooth muscle — no resolved target expressed herelung — no resolved target expressed hereliver — 1138.4 nTPM, from F2kidney — 0.2 nTPM, from F2stomach — 0.3 nTPM, from F2duodenum — no resolved target expressed heresmall intestine — no resolved target expressed herecolon — 0.3 nTPM, from F2adrenal gland — no resolved target expressed herethyroid gland — no resolved target expressed herepancreas — no resolved target expressed hereurinary bladder — 0.2 nTPM, from F2skeletal muscle — no resolved target expressed herespleen — 0.5 nTPM, from F2salivary gland — no resolved target expressed here
01138 nTPM

Square-root ramp · shared scale across both plates

Shading is transcript level — not affinity, and not affinity combined with expression. Outlined but unshaded organs hold none of F2 transcript above the atlas’s detection threshold. Anatomy from EMBL-EBI Anatomogram (Apache License 2.0); regions identified by Uberon (uberon.org), CC BY 3.0.

Brain · 5

  • cerebellum0.9 nTPM
  • basal ganglia0.2 nTPM
  • cerebral cortex0.1 nTPM
  • hypothalamus0.1 nTPM
  • pituitary gland0.1 nTPM

Peripheral and autonomic · 7

  • liver1138.4 nTPM
  • spleen0.5 nTPM
  • stomach 10.3 nTPM
  • colon0.3 nTPM
  • kidney0.2 nTPM
  • urinary bladder0.2 nTPM
  • heart muscle0.1 nTPM

Transcript is not protein. These are RNA levels for F2, shaded on √nTPM so that a three-order range stays legible — on a linear ramp every region but the strongest would read as blank, which looks like absence rather than less. A region carrying no shading is one the atlas reports no consensus value for, not one where the gene is silent. And a gene being transcribed somewhere is not evidence that any compound reaches it. Human Protein Atlas, RNA expression, nTPM (normalized transcripts per million), consensus tissue dataset.

IV · Evidence

Every measurement at this target

Each row links to the ChEMBL assay it came from.

Functional readouts 6

IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.

TargetClassTypeValue (nM)pXOrganismAssay
ProthrombinUnclassifiedAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291794
ProthrombinUnclassifiedAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291794
ProthrombinUnclassifiedAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291794
ProthrombinUnclassifiedAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291794
ProthrombinUnclassifiedAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291794
ProthrombinUnclassifiedIC50— no normalized value— value does not convert to pXBos taurusCHEMBL1964096
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