Prelamin-A/C

Prelamin-A/C

Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane10080180,10580070,10587585,10814726,11799477,12075506,12927431,15317753,18551513,18611980,2188730,22431096,2344612,23666920,24741066,31434876,31548606,37788673,37832547. Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics10080180,10580070,10587585,10814726,11799477,12075506,12927431,15317753,18551513,18611980,22431096,23666920,24741066,31548606,37788673,37832547. Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties23990565,25127216. The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively2188730,2344612. Lamin A and C are present in equal amounts in the lamina of mammals10080180,10580070,10587585,10814726,11799477,12075506,12927431,15317753,18551513,18611980,22431096,23666920,31548606. Also involved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends31548606. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation10080180,10814726,11799477,18551513,22431096. Required for osteoblastogenesis and bone formation12075506,15317753,18611980. Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone10587585. Required for cardiac homeostasis10580070,12927431,18611980,23666920

Prelamin-A/C can accelerate smooth muscle cell senescence20458013. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence20458013

Quoted from UniProt’s FUNCTION annotation for P02545 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

Where it sits in the cell

• Nuclear speckles

Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.

UniProt, curated Nucleus lamina · Nucleus envelope · Nucleus, nucleoplasm · Nucleus matrix · Nucleus speckle

Expression by cell type

Single cell type RNA, the 2 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.

• Mast cells2,669 nCPM
• Schwann cells1,415.6 nCPM