POU domain, class 2, transcription factor 2
Matched no rule. Shown as-is rather than assigned a class by guesswork. Values below are reported as measured; because this is not a molecular target, they are not treated as affinities anywhere on this site.
- Measurements
- 1
- Compounds
- 1
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
POU domain, class 2, transcription factor 2
Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3')2904654,7859290. Regulates IL6 expression in B cells with POU2AF1 (By similarity). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression2901913,2904654. Modulates transcription transactivation by NR3C1, AR and PGR10480874
Activates the U2 small nuclear RNA (snRNA) promoter
Quoted from UniProt’s FUNCTION annotation for P09086 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
Where it sits in the cell
- Nucleoplasm
- Vesicles
Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.
UniProt, curated Cytoplasm · Nucleus
Expression by cell type
Single cell type RNA, the 11 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- B-cells340.8 nCPM
- monocytes259 nCPM
- cDC168.4 nCPM
- Neutrophils165.8 nCPM
- Early primary spermatocytes156.4 nCPM
- Plasma cells145.3 nCPM
- Microglia129.5 nCPM
- Macrophages119.6 nCPM
- Monocyte progenitors118.5 nCPM
- Kupffer cells108.6 nCPM
- Retinal bipolar cells104.2 nCPM
Expression by tissue
The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.
- lymphoid tissue47.4 nTPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Other measurements 1
Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| POU domain, class 2, transcription factor 2 | Unclassified | Ratio | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5119576 |