TargetUnclassified

POU domain, class 2, transcription factor 1

Matched no rule. Shown as-is rather than assigned a class by guesswork. Values below are reported as measured; because this is not a molecular target, they are not treated as affinities anywhere on this site.

Measurements: 1
Compounds: 1
Binding constants: 0
Median pX: —

I · Identity

What this target is

Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.

Protein

PO2F1_HUMANPOU2F1Homo sapiens

POU domain, class 2, transcription factor 1

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR

(Microbial infection) In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes

Quoted from UniProt’s FUNCTION annotation for P14859 (reviewed).

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

Partner	Combined	Experiment	Database	Text mining
POU2AF1	0.995	0.972	0.000	0.843
HCFC1	0.993	0.636	0.000	0.982
POU2F2	0.981	0.800	0.900	0.129
POU2F3	0.980	0.800	0.900	0.111
SOX2	0.973	0.921	0.400	0.471
BRCA1	0.919	0.722	0.000	0.713
EP300	0.917	0.061	0.800	0.560
SP1	0.872	0.629	0.500	0.348
HCFC2	0.841	0.071	0.000	0.836
XRCC6	0.841	0.736	0.000	0.419

Where it sits in the cell

Nucleoplasm
Endoplasmic reticulumadditional
Vesiclesadditional

Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.

UniProt, curated Nucleus

IV · Evidence

Every measurement at this target

Each row links to the ChEMBL assay it came from.

Other measurements 1

Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.

Target	Class	Type	Value (nM)	pX	Organism	Assay
POU domain, class 2, transcription factor 1	Unclassified	Ratio	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL5119577

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