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PsychedeliaDokholyan Laboratory
TargetUnclassified

Peripheral myelin protein 22

Matched no rule. Shown as-is rather than assigned a class by guesswork. Values below are reported as measured; because this is not a molecular target, they are not treated as affinities anywhere on this site.

Measurements
9
Compounds
8
Binding constants
0
Median pX
—

I · Identity

What this target is

Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.

Protein

PMP22_HUMANPMP22Homo sapiens

Peripheral myelin protein 22

Might be involved in growth regulation, and in myelinization in the peripheral nervous system

Quoted from UniProt’s FUNCTION annotation for Q01453 (reviewed).

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

PartnerCombinedExperimentDatabaseText mining
RNMT0.9710.0000.0000.971
MPZL10.9550.0000.0000.955
GJB10.9420.0000.0000.941
EGR20.9160.2920.5000.780
CLDN110.8560.0000.0000.854
PRX0.7840.0000.0000.784
SH3TC20.7250.0000.0000.725
MTMR20.7230.0000.0000.723
RNGTT0.7180.0000.0000.718
SOX100.6460.0000.5000.303

Where it sits in the cell

UniProt, curated Cell membrane

Expression by cell type

Single cell type RNA, the 7 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.

  • Schwann cells1,577.5 nCPM
  • Hofbauer cells1,289.5 nCPM
  • Enterocytes1,064 nCPM
  • Fibroblasts459.4 nCPM
  • Melanocytes443.3 nCPM
  • Decidual stromal cells388 nCPM
  • Myosatellite cells291.5 nCPM

II · Anatomy

Where the gene is transcribed

The same two atlases the compound plates use, asked about this gene alone. Brain on the left, peripheral and autonomic tissues on the right.

Brain

cerebral cortex — 74.1 nTPM, from PMP22cerebellum — 18.2 nTPM, from PMP22hippocampal formation — 111.6 nTPM, from PMP22amygdala — 89.2 nTPM, from PMP22hypothalamus — 58.0 nTPM, from PMP22thalamus — no resolved target expressed herebasal ganglia — 108.6 nTPM, from PMP22medulla oblongata — no resolved target expressed here

basal ganglia: drawn as the caudate nucleus, putamen and globus pallidus.

Measured but not drawn — this anatomogram has no outline for them: spinal cord 229.5, midbrain 115.7, pituitary gland 21.0, retina 6.1.

Body

heart — 140.9 nTPM, from PMP22smooth muscle — 114.0 nTPM, from PMP22lung — 184.5 nTPM, from PMP22liver — 9.6 nTPM, from PMP22kidney — 39.1 nTPM, from PMP22stomach — 84.5 nTPM, from PMP22duodenum — 39.2 nTPM, from PMP22small intestine — 225.1 nTPM, from PMP22colon — 187.3 nTPM, from PMP22adrenal gland — 42.6 nTPM, from PMP22thyroid gland — 84.5 nTPM, from PMP22pancreas — 18.5 nTPM, from PMP22urinary bladder — 195.0 nTPM, from PMP22skeletal muscle — 183.1 nTPM, from PMP22spleen — 22.9 nTPM, from PMP22salivary gland — 66.7 nTPM, from PMP22
0230 nTPM

Square-root ramp · shared scale across both plates

Shading is transcript level — not affinity, and not affinity combined with expression. Outlined but unshaded organs hold none of PMP22 transcript above the atlas’s detection threshold. Anatomy from EMBL-EBI Anatomogram (Apache License 2.0); regions identified by Uberon (uberon.org), CC BY 3.0.

Brain · 10

  • spinal cord229.5 nTPM
  • midbrain115.7 nTPM
  • hippocampal formation111.6 nTPM
  • basal ganglia108.6 nTPM
  • amygdala89.2 nTPM
  • cerebral cortex74.1 nTPM
  • hypothalamus58.0 nTPM
  • pituitary gland21.0 nTPM
  • cerebellum18.2 nTPM
  • retina6.1 nTPM

Peripheral and autonomic · 16

  • small intestine225.1 nTPM
  • urinary bladder195.0 nTPM
  • colon187.3 nTPM
  • lung184.5 nTPM
  • skeletal muscle183.1 nTPM
  • heart muscle140.9 nTPM
  • smooth muscle114.0 nTPM
  • stomach 184.5 nTPM
  • thyroid gland84.5 nTPM
  • salivary gland66.7 nTPM
  • adrenal gland42.6 nTPM
  • duodenum39.2 nTPM
  • kidney39.1 nTPM
  • spleen22.9 nTPM
  • pancreas18.5 nTPM
  • liver9.6 nTPM

Transcript is not protein. These are RNA levels for PMP22, shaded on √nTPM so that a three-order range stays legible — on a linear ramp every region but the strongest would read as blank, which looks like absence rather than less. A region carrying no shading is one the atlas reports no consensus value for, not one where the gene is silent. And a gene being transcribed somewhere is not evidence that any compound reaches it. Human Protein Atlas, RNA expression, nTPM (normalized transcripts per million), consensus tissue dataset.

IV · Evidence

Every measurement at this target

Each row links to the ChEMBL assay it came from.

Functional readouts 9

IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.

TargetClassTypeValue (nM)pXOrganismAssay
Peripheral myelin protein 22UnclassifiedPotency— no normalized value— value does not convert to pXRattus norvegicusCHEMBL1964081
Peripheral myelin protein 22UnclassifiedPotency— no normalized value— value does not convert to pXRattus norvegicusCHEMBL1964081
Peripheral myelin protein 22UnclassifiedPotency— no normalized value— value does not convert to pXRattus norvegicusCHEMBL1964081
Peripheral myelin protein 22UnclassifiedPotency— no normalized value— value does not convert to pXRattus norvegicusCHEMBL1964081
Peripheral myelin protein 22UnclassifiedPotency— no normalized value— value does not convert to pXRattus norvegicusCHEMBL1964081
Peripheral myelin protein 22UnclassifiedPotency— no normalized value— value does not convert to pXRattus norvegicusCHEMBL1964081
Peripheral myelin protein 22UnclassifiedPotency— no normalized value— value does not convert to pXRattus norvegicusCHEMBL1964081
Peripheral myelin protein 22UnclassifiedPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1614171
Peripheral myelin protein 22UnclassifiedPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1614171
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