P2X purinoceptor 7
Matched no rule. Shown as-is rather than assigned a class by guesswork. Values below are reported as measured; because this is not a molecular target, they are not treated as affinities anywhere on this site.
- Measurements
- 5
- Compounds
- 1
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
P2X purinoceptor 7
ATP-gated nonselective transmembrane cation channel that requires high millimolar concentrations of ATP for activation17483156,25281740,9038151. Upon ATP binding, it rapidly opens to allow the influx of small cations Na(+) and Ca(2+), and the K(+) efflux17483156,20453110,28235784,39262850. Also has the ability to form a large pore in the cell membrane, allowing the passage of large cationic molecules17483156. In microglia, may mediate NADPH transport across the plasma membrane39142135. In immune cells, P2RX7 acts as a molecular sensor in pathological inflammatory states by detecting and responding to high local concentrations of extracellar ATP. In microglial cells, P2RX7 activation leads to the release of pro-inflammatory cytokines, such as IL-1beta and IL-18, through the activation of the NLRP3 inflammasome and caspase-126877061. Cooperates with KCNK6 to activate NLRP3 inflammasome (By similarity). Activates death pathways leading to apoptosis and autophagy21821797,23303206,28326637. Activates death pathways leading to pyroptosis (By similarity)
Shows ion channel activity but no macropore function
Non-functional channel
Non-functional channel
Quoted from UniProt’s FUNCTION annotation for Q99572 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
Where it sits in the cell
UniProt, curated Cell membrane
Expression by cell type
Single cell type RNA, the 7 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Oligodendrocytes350.2 nCPM
- Melanocytes194.7 nCPM
- Oligodendrocyte progenitor cells187.4 nCPM
- Microglia151.5 nCPM
- cDC108.6 nCPM
- Macrophages84.3 nCPM
- monocytes81.3 nCPM
Expression by tissue
The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.
- brain16.8 nTPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Other measurements 5
Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| P2X purinoceptor 7 | Unclassified | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL4620831 |
| P2X purinoceptor 7 | Unclassified | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL4620832 |
| P2X purinoceptor 7 | Unclassified | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL4620833 |
| P2X purinoceptor 7 | Unclassified | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL4620834 |
| P2X purinoceptor 7 | Unclassified | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL4620835 |