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PsychedeliaDokholyan Laboratory
TargetUnclassified

Neutrophil elastase

Matched no rule. Shown as-is rather than assigned a class by guesswork. Values below are reported as measured; because this is not a molecular target, they are not treated as affinities anywhere on this site.

Measurements
14
Compounds
7
Binding constants
7
Median pX
—

I · Identity

What this target is

Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.

Protein

ELNE_HUMANELANEHomo sapiens

Neutrophil elastase

Serine protease that modifies the functions of natural killer cells, monocytes and granulocytes15140022. Shows microbicidal activity in neutrophils by mediating cleavage and degradation of bacterial proteins10947984,25161283. Capable of killing E.coli but not S.aureus in vitro; digests outer membrane protein A (ompA) in E.coli and K.pneumoniae10947984. Involved for the formation of neutrophil extracellular traps (NETs): translocates into the nucleus downstream of MPO and mediates degadation of histone H4, thereby participating to chromatin decondensation20974816,25066128,28574339. NETs are mainly composed of DNA fibers and are released by neutrophils to trap pathogens during inflammation20974816,25066128,28574339. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis15140022. Promotes cleavage of GSDMB, thereby inhibiting pyroptosis36899106. Promotes blood coagulation20676107. Through the activation of the platelet fibrinogen receptor integrin alpha-IIb/beta-3, potentiates platelet aggregation induced by a threshold concentration of cathepsin G (CTSG)25211214,9111081. Cleaves and thus inactivates tissue factor pathway inhibitor (TFPI)20676107,25211214
(Microbial infection) Inhibited reversibly by S.aureus serine protease inhibitors Eap, EapH1 and EapH2, impairing microbicidal activity in neutrophils

Quoted from UniProt’s FUNCTION annotation for P08246 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

PartnerCombinedExperimentDatabaseText mining
SERPINA10.9990.6100.0000.999
AZU10.9990.0000.0000.699
DEFA40.9990.0710.0000.507
MPO0.9990.1640.0000.999
CTSG0.9990.0000.4000.985
SLPI0.9980.9460.0000.981
LTF0.9970.0520.0000.996
PRTN30.9970.0000.4000.978
CAMP0.9910.0000.0000.983
BPI0.9750.0000.0000.897

Where it sits in the cell

  • Vesicles
  • Golgi apparatusadditional

Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.

UniProt, curated Cytoplasmic vesicle, phagosome · Lysosome · Cytolytic granule · Nucleus

Expression by cell type

Single cell type RNA, the 2 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.

  • Monocyte progenitors552.5 nCPM
  • Neutrophil progenitors524.5 nCPM

Expression by tissue

The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.

  • bone marrow3,672 nTPM

II · Anatomy

Where the gene is transcribed

The same two atlases the compound plates use, asked about this gene alone. Brain on the left, peripheral and autonomic tissues on the right.

Brain

cerebral cortex — 1.0 nTPM, from ELANEcerebellum — 0.1 nTPM, from ELANEhippocampal formation — 0.4 nTPM, from ELANEamygdala — 0.8 nTPM, from ELANEhypothalamus — 0.3 nTPM, from ELANEthalamus — no resolved target expressed herebasal ganglia — 0.5 nTPM, from ELANEmedulla oblongata — no resolved target expressed here

basal ganglia: drawn as the caudate nucleus, putamen and globus pallidus.

Measured but not drawn — this anatomogram has no outline for them: pituitary gland 1.2, midbrain 0.3, spinal cord 0.2.

Body

heart — 3.9 nTPM, from ELANEsmooth muscle — 0.1 nTPM, from ELANElung — 18.9 nTPM, from ELANEliver — 3.1 nTPM, from ELANEkidney — 0.8 nTPM, from ELANEstomach — 1.4 nTPM, from ELANEduodenum — 0.3 nTPM, from ELANEsmall intestine — 1.8 nTPM, from ELANEcolon — 2.0 nTPM, from ELANEadrenal gland — 1.0 nTPM, from ELANEthyroid gland — 3.0 nTPM, from ELANEpancreas — 0.5 nTPM, from ELANEurinary bladder — 1.7 nTPM, from ELANEskeletal muscle — 1.4 nTPM, from ELANEspleen — 42.4 nTPM, from ELANEsalivary gland — 2.2 nTPM, from ELANE
042 nTPM

Square-root ramp · shared scale across both plates

Shading is transcript level — not affinity, and not affinity combined with expression. Outlined but unshaded organs hold none of ELANE transcript above the atlas’s detection threshold. Anatomy from EMBL-EBI Anatomogram (Apache License 2.0); regions identified by Uberon (uberon.org), CC BY 3.0.

Brain · 9

  • pituitary gland1.2 nTPM
  • cerebral cortex1.0 nTPM
  • amygdala0.8 nTPM
  • basal ganglia0.5 nTPM
  • hippocampal formation0.4 nTPM
  • hypothalamus0.3 nTPM
  • midbrain0.3 nTPM
  • spinal cord0.2 nTPM
  • cerebellum0.1 nTPM

Peripheral and autonomic · 16

  • spleen42.4 nTPM
  • lung18.9 nTPM
  • heart muscle3.9 nTPM
  • liver3.1 nTPM
  • thyroid gland3.0 nTPM
  • salivary gland2.2 nTPM
  • colon2.0 nTPM
  • small intestine1.8 nTPM
  • urinary bladder1.7 nTPM
  • stomach 11.4 nTPM
  • skeletal muscle1.4 nTPM
  • adrenal gland1.0 nTPM
  • kidney0.8 nTPM
  • pancreas0.5 nTPM
  • duodenum0.3 nTPM
  • smooth muscle0.1 nTPM

Transcript is not protein. These are RNA levels for ELANE, shaded on √nTPM so that a three-order range stays legible — on a linear ramp every region but the strongest would read as blank, which looks like absence rather than less. A region carrying no shading is one the atlas reports no consensus value for, not one where the gene is silent. And a gene being transcribed somewhere is not evidence that any compound reaches it. Human Protein Atlas, RNA expression, nTPM (normalized transcripts per million), consensus tissue dataset.

IV · Evidence

Every measurement at this target

Each row links to the ChEMBL assay it came from.

Equilibrium binding constants 7

Ki and Kd — a concentration at equilibrium. Directly comparable across rows at the same target.

TargetClassTypeValue (nM)pXOrganismAssay
Neutrophil elastaseUnclassifiedKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909195
Neutrophil elastaseUnclassifiedKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909195
Neutrophil elastaseUnclassifiedKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909195
Neutrophil elastaseUnclassifiedKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909195
Neutrophil elastaseUnclassifiedKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909195
Neutrophil elastaseUnclassifiedKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909195
Neutrophil elastaseUnclassifiedKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909195

Functional readouts 7

IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.

TargetClassTypeValue (nM)pXOrganismAssay
Neutrophil elastaseUnclassifiedIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909195
Neutrophil elastaseUnclassifiedIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909195
Neutrophil elastaseUnclassifiedIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909195
Neutrophil elastaseUnclassifiedIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909195
Neutrophil elastaseUnclassifiedIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909195
Neutrophil elastaseUnclassifiedIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909195
Neutrophil elastaseUnclassifiedIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909195
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