TargetCell lines

MDCK

Phenotypic screens. A value here is a cellular response, not a binding affinity. Values below are reported as measured; because this is not a molecular target, they are not treated as affinities anywhere on this site.

Measurements: 17
Compounds: 6
Binding constants: 0
Median pX: —

I · Identity

What this target is

Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.

MDCK has no protein record here. A name resolves when ChEMBL’s own target record gives an accession, when the name appears verbatim in a gene’s synonym list, or when it matches a UniProt protein name exactly. Guessing from a name that merely looks like a receptor is how a histone gene ends up filed as an adrenoceptor.

IV · Evidence

Every measurement at this target

Each row links to the ChEMBL assay it came from.

Functional readouts 1

IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.

Target	Class	Type	Value (nM)	pX	Organism	Assay
MDCK	Cell lines	EC50	— no normalized value	— value does not convert to pX	Canis lupus familiaris	CHEMBL713908

Other measurements 16

Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.

Target	Class	Type	Value (nM)	pX	Organism	Assay
MDCK	Cell lines	Ratio	— no normalized value	— value does not convert to pX	Canis lupus familiaris	CHEMBL861744
MDCK	Cell lines	Ratio	— no normalized value	— value does not convert to pX	Canis lupus familiaris	CHEMBL861800
MDCK	Cell lines	Papp	— no normalized value	— value does not convert to pX	Canis lupus familiaris	CHEMBL863567
MDCK	Cell lines	Papp	— no normalized value	— value does not convert to pX	Canis lupus familiaris	CHEMBL861743
MDCK	Cell lines	Papp	— no normalized value	— value does not convert to pX	Canis lupus familiaris	CHEMBL861747
MDCK	Cell lines	Papp	— no normalized value	— value does not convert to pX	Canis lupus familiaris	CHEMBL861799
MDCK	Cell lines	permeability	— no normalized value	— value does not convert to pX	Canis lupus familiaris	CHEMBL3363138
MDCK	Cell lines	permeability	— no normalized value	— value does not convert to pX	Canis lupus familiaris	CHEMBL3363139
MDCK	Cell lines	CC50	— no normalized value	— value does not convert to pX	Canis lupus familiaris	CHEMBL713282
MDCK	Cell lines	Papp	— no normalized value	— value does not convert to pX	Canis lupus familiaris	CHEMBL3812912
MDCK	Cell lines	Ratio	— no normalized value	— value does not convert to pX	Canis lupus familiaris	CHEMBL3812913
MDCK	Cell lines	permeability	— no normalized value	— value does not convert to pX	Canis lupus familiaris	CHEMBL2033722
MDCK	Cell lines	Ratio	— no normalized value	— value does not convert to pX	Canis lupus familiaris	CHEMBL2065581
MDCK	Cell lines	Papp	— no normalized value	— value does not convert to pX	Canis lupus familiaris	CHEMBL2065580
MDCK	Cell lines	Papp	— no normalized value	— value does not convert to pX	Canis lupus familiaris	CHEMBL1041008
MDCK	Cell lines	Ratio	— no normalized value	— value does not convert to pX	Canis lupus familiaris	CHEMBL1041021

← All targets