TargetUnclassified

Matrix metalloproteinase-9

Matched no rule. Shown as-is rather than assigned a class by guesswork. Values below are reported as measured; because this is not a molecular target, they are not treated as affinities anywhere on this site.

Measurements: 14
Compounds: 7
Binding constants: 7
Median pX: —

I · Identity

What this target is

Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.

Protein

MMP9_HUMANMMP9Homo sapiens

Matrix metalloproteinase-9

Matrix metalloproteinase that plays an essential role in local proteolysis of the extracellular matrix and in leukocyte migration12879005,1480034,2551898. Could play a role in bone osteoclastic resorption (By similarity). Cleaves KiSS1 at a Gly-|-Leu bond12879005. Cleaves NINJ1 to generate the Secreted ninjurin-1 form32883094. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments1480034. Degrades fibronectin but not laminin or Pz-peptide

Quoted from UniProt’s FUNCTION annotation for P14780 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

Partner	Combined	Experiment	Database	Text mining
TIMP1	0.999	0.572	0.900	0.999
CD44	0.998	0.000	0.500	0.995
TIMP2	0.998	0.303	0.000	0.997
LCN2	0.998	0.422	0.400	0.995
THBS1	0.997	0.298	0.900	0.963
TIMP3	0.995	0.303	0.900	0.942
CTSG	0.992	0.000	0.400	0.987
DMP1	0.982	0.000	0.000	0.982
ELN	0.979	0.292	0.000	0.972
MMP1	0.974	0.000	0.900	0.725

Where it sits in the cell

Cytosol

Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.

UniProt, curated Secreted, extracellular space, extracellular matrix

Expression by cell type

Single cell type RNA, the 2 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.

Neutrophil progenitors1,633.8 nCPM
Neutrophils1,533.7 nCPM

Expression by tissue

The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.

bone marrow355.6 nTPM
lymphoid tissue102.5 nTPM

IV · Evidence

Every measurement at this target

Each row links to the ChEMBL assay it came from.

Equilibrium binding constants 7

Ki and Kd — a concentration at equilibrium. Directly comparable across rows at the same target.

Target	Class	Type	Value (nM)	pX	Organism	Assay
Matrix metalloproteinase-9	Unclassified	Ki	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL1909197
Matrix metalloproteinase-9	Unclassified	Ki	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL1909197
Matrix metalloproteinase-9	Unclassified	Ki	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL1909197
Matrix metalloproteinase-9	Unclassified	Ki	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL1909197
Matrix metalloproteinase-9	Unclassified	Ki	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL1909197
Matrix metalloproteinase-9	Unclassified	Ki	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL1909197
Matrix metalloproteinase-9	Unclassified	Ki	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL1909197

Functional readouts 7

IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.

Target	Class	Type	Value (nM)	pX	Organism	Assay
Matrix metalloproteinase-9	Unclassified	IC50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL1909197
Matrix metalloproteinase-9	Unclassified	IC50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL1909197
Matrix metalloproteinase-9	Unclassified	IC50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL1909197
Matrix metalloproteinase-9	Unclassified	IC50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL1909197
Matrix metalloproteinase-9	Unclassified	IC50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL1909197
Matrix metalloproteinase-9	Unclassified	IC50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL1909197
Matrix metalloproteinase-9	Unclassified	IC50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL1909197

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