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PsychedeliaDokholyan Laboratory
TargetUnclassified

Interstitial collagenase

Matched no rule. Shown as-is rather than assigned a class by guesswork. Values below are reported as measured; because this is not a molecular target, they are not treated as affinities anywhere on this site.

Measurements
14
Compounds
7
Binding constants
7
Median pX
—

I · Identity

What this target is

Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.

Protein

MMP1_HUMANMMP1Homo sapiens

Interstitial collagenase

Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X1645757,2153297,2557822. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity16807369

Quoted from UniProt’s FUNCTION annotation for P03956 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

PartnerCombinedExperimentDatabaseText mining
TIMP10.9990.9350.4000.984
MMP30.9850.0000.9000.597
BSG0.9770.3290.9000.697
MMP90.9740.0000.9000.725
TIMP20.9360.1860.0000.921
MMP20.9300.0000.9000.215
F2R0.8970.3980.0000.828
MMP70.8780.0000.5000.727
IL1B0.8730.0700.0000.849
STAT30.8690.2260.5000.686

Where it sits in the cell

  • Vesicles

Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.

UniProt, curated Secreted, extracellular space, extracellular matrix

Expression by cell type

Single cell type RNA, the 9 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.

  • Endometrial secretory cells208.7 nCPM
  • Pancreatic duct cells159.1 nCPM
  • Gastric progenitor cells130.7 nCPM
  • Ocular epithelial cells119.4 nCPM
  • Fibroblasts91.6 nCPM
  • Mucous neck cells49.6 nCPM
  • Gastric chief cells48.1 nCPM
  • Parietal cells37.1 nCPM
  • Platelets35.1 nCPM

Expression by tissue

The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.

  • gallbladder70.7 nTPM
  • urinary bladder48.6 nTPM
  • stomach 144.2 nTPM

II · Anatomy

Where the gene is transcribed

The same two atlases the compound plates use, asked about this gene alone. Brain on the left, peripheral and autonomic tissues on the right.

Brain

cerebral cortex — 0.5 nTPM, from MMP1cerebellum — no resolved target expressed herehippocampal formation — no resolved target expressed hereamygdala — no resolved target expressed herehypothalamus — 0.1 nTPM, from MMP1thalamus — no resolved target expressed herebasal ganglia — no resolved target expressed heremedulla oblongata — no resolved target expressed here

basal ganglia: drawn as the caudate nucleus, putamen and globus pallidus.

Measured but not drawn — this anatomogram has no outline for them: pituitary gland 0.1.

Body

heart — 0.3 nTPM, from MMP1smooth muscle — 1.1 nTPM, from MMP1lung — 6.7 nTPM, from MMP1liver — 0.7 nTPM, from MMP1kidney — 0.5 nTPM, from MMP1stomach — 44.2 nTPM, from MMP1duodenum — 7.5 nTPM, from MMP1small intestine — 12.2 nTPM, from MMP1colon — 5.9 nTPM, from MMP1adrenal gland — no resolved target expressed herethyroid gland — 0.2 nTPM, from MMP1pancreas — 1.1 nTPM, from MMP1urinary bladder — 48.6 nTPM, from MMP1skeletal muscle — no resolved target expressed herespleen — 0.9 nTPM, from MMP1salivary gland — 5.8 nTPM, from MMP1
049 nTPM

Square-root ramp · shared scale across both plates

Shading is transcript level — not affinity, and not affinity combined with expression. Outlined but unshaded organs hold none of MMP1 transcript above the atlas’s detection threshold. Anatomy from EMBL-EBI Anatomogram (Apache License 2.0); regions identified by Uberon (uberon.org), CC BY 3.0.

Brain · 3

  • cerebral cortex0.5 nTPM
  • hypothalamus0.1 nTPM
  • pituitary gland0.1 nTPM

Peripheral and autonomic · 14

  • urinary bladder48.6 nTPM
  • stomach 144.2 nTPM
  • small intestine12.2 nTPM
  • duodenum7.5 nTPM
  • lung6.7 nTPM
  • colon5.9 nTPM
  • salivary gland5.8 nTPM
  • smooth muscle1.1 nTPM
  • pancreas1.1 nTPM
  • spleen0.9 nTPM
  • liver0.7 nTPM
  • kidney0.5 nTPM
  • heart muscle0.3 nTPM
  • thyroid gland0.2 nTPM

Transcript is not protein. These are RNA levels for MMP1, shaded on √nTPM so that a three-order range stays legible — on a linear ramp every region but the strongest would read as blank, which looks like absence rather than less. A region carrying no shading is one the atlas reports no consensus value for, not one where the gene is silent. And a gene being transcribed somewhere is not evidence that any compound reaches it. Human Protein Atlas, RNA expression, nTPM (normalized transcripts per million), consensus tissue dataset.

IV · Evidence

Every measurement at this target

Each row links to the ChEMBL assay it came from.

Equilibrium binding constants 7

Ki and Kd — a concentration at equilibrium. Directly comparable across rows at the same target.

TargetClassTypeValue (nM)pXOrganismAssay
Interstitial collagenaseUnclassifiedKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909196
Interstitial collagenaseUnclassifiedKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909196
Interstitial collagenaseUnclassifiedKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909196
Interstitial collagenaseUnclassifiedKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909196
Interstitial collagenaseUnclassifiedKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909196
Interstitial collagenaseUnclassifiedKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909196
Interstitial collagenaseUnclassifiedKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909196

Functional readouts 7

IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.

TargetClassTypeValue (nM)pXOrganismAssay
Interstitial collagenaseUnclassifiedIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909196
Interstitial collagenaseUnclassifiedIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909196
Interstitial collagenaseUnclassifiedIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909196
Interstitial collagenaseUnclassifiedIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909196
Interstitial collagenaseUnclassifiedIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909196
Interstitial collagenaseUnclassifiedIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909196
Interstitial collagenaseUnclassifiedIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909196
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