Skip to content
PsychedeliaDokholyan Laboratory
TargetUnclassified

Huntingtin

Matched no rule. Shown as-is rather than assigned a class by guesswork. Values below are reported as measured; because this is not a molecular target, they are not treated as affinities anywhere on this site.

Measurements
4
Compounds
4
Binding constants
0
Median pX
—

I · Identity

What this target is

Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.

Protein

HD_HUMANHTTHomo sapiens

Huntingtin

May play a role in microtubule-mediated transport or vesicle function
Promotes the formation of autophagic vesicles

Quoted from UniProt’s FUNCTION annotation for P42858 (reviewed).

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

PartnerCombinedExperimentDatabaseText mining
HAP10.9990.8220.0000.997
TP530.9980.3070.8000.989
F8A20.9980.9600.0000.974
CREBBP0.9970.8320.0000.982
OPTN0.9970.7770.0000.990
ITPR10.9950.2970.9000.944
ZDHHC170.9950.7110.0000.986
TAF40.9940.5100.8000.948
GAPDH0.9930.5130.0000.987
REST0.9910.0950.9000.911

Where it sits in the cell

  • Nucleoplasm
  • Cytosoladditional

Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.

UniProt, curated Cytoplasm · Nucleus · Early endosome · Cytoplasmic vesicle, autophagosome

Expression by cell type

Single cell type RNA, the 1 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.

  • Cone photoreceptor cells349.8 nCPM

II · Anatomy

Where the gene is transcribed

The same two atlases the compound plates use, asked about this gene alone. Brain on the left, peripheral and autonomic tissues on the right.

Brain

cerebral cortex — 16.7 nTPM, from HTTcerebellum — 15.8 nTPM, from HTThippocampal formation — 13.2 nTPM, from HTTamygdala — 12.0 nTPM, from HTThypothalamus — 7.0 nTPM, from HTTthalamus — no resolved target expressed herebasal ganglia — 9.8 nTPM, from HTTmedulla oblongata — no resolved target expressed here

basal ganglia: drawn as the caudate nucleus, putamen and globus pallidus.

Measured but not drawn — this anatomogram has no outline for them: retina 9.5, pituitary gland 8.4, midbrain 6.8, spinal cord 6.2.

Body

heart — 6.6 nTPM, from HTTsmooth muscle — 5.4 nTPM, from HTTlung — 9.3 nTPM, from HTTliver — 8.4 nTPM, from HTTkidney — 7.4 nTPM, from HTTstomach — 8.3 nTPM, from HTTduodenum — 5.7 nTPM, from HTTsmall intestine — 8.9 nTPM, from HTTcolon — 7.6 nTPM, from HTTadrenal gland — 8.7 nTPM, from HTTthyroid gland — 8.4 nTPM, from HTTpancreas — 20.1 nTPM, from HTTurinary bladder — 7.3 nTPM, from HTTskeletal muscle — 14.3 nTPM, from HTTspleen — 10.7 nTPM, from HTTsalivary gland — 6.7 nTPM, from HTT
020 nTPM

Square-root ramp · shared scale across both plates

Shading is transcript level — not affinity, and not affinity combined with expression. Outlined but unshaded organs hold none of HTT transcript above the atlas’s detection threshold. Anatomy from EMBL-EBI Anatomogram (Apache License 2.0); regions identified by Uberon (uberon.org), CC BY 3.0.

Brain · 10

  • cerebral cortex16.7 nTPM
  • cerebellum15.8 nTPM
  • hippocampal formation13.2 nTPM
  • amygdala12.0 nTPM
  • basal ganglia9.8 nTPM
  • retina9.5 nTPM
  • pituitary gland8.4 nTPM
  • hypothalamus7.0 nTPM
  • midbrain6.8 nTPM
  • spinal cord6.2 nTPM

Peripheral and autonomic · 16

  • pancreas20.1 nTPM
  • skeletal muscle14.3 nTPM
  • spleen10.7 nTPM
  • lung9.3 nTPM
  • small intestine8.9 nTPM
  • adrenal gland8.7 nTPM
  • liver8.4 nTPM
  • thyroid gland8.4 nTPM
  • stomach 18.3 nTPM
  • colon7.6 nTPM
  • kidney7.4 nTPM
  • urinary bladder7.3 nTPM
  • salivary gland6.7 nTPM
  • heart muscle6.6 nTPM
  • duodenum5.7 nTPM
  • smooth muscle5.4 nTPM

Transcript is not protein. These are RNA levels for HTT, shaded on √nTPM so that a three-order range stays legible — on a linear ramp every region but the strongest would read as blank, which looks like absence rather than less. A region carrying no shading is one the atlas reports no consensus value for, not one where the gene is silent. And a gene being transcribed somewhere is not evidence that any compound reaches it. Human Protein Atlas, RNA expression, nTPM (normalized transcripts per million), consensus tissue dataset.

IV · Evidence

Every measurement at this target

Each row links to the ChEMBL assay it came from.

Functional readouts 4

IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.

TargetClassTypeValue (nM)pXOrganismAssay
HuntingtinUnclassifiedPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1613918
HuntingtinUnclassifiedPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1613918
HuntingtinUnclassifiedPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1613918
HuntingtinUnclassifiedPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1613918
← All targets