TargetCell lines

HCT-116

Phenotypic screens. A value here is a cellular response, not a binding affinity. Values below are reported as measured; because this is not a molecular target, they are not treated as affinities anywhere on this site.

Measurements: 31
Compounds: 15
Binding constants: 0
Median pX: —

I · Identity

What this target is

Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.

HCT-116 is a cell line or an assay label, not a protein, so there is no gene to describe. Its measurements are still shown below — they are real, and they are measurements of what a compound did in that system rather than of what it binds.

Resolver said a cell line or assay label, not a gene — recorded by tools/fetch_expression.py, not written here.

IV · Evidence

Every measurement at this target

Each row links to the ChEMBL assay it came from.

Functional readouts 16

IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.

Target	Class	Type	Value (nM)	pX	Organism	Assay
HCT-116	Cell lines	IC50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL4321392
HCT-116	Cell lines	IC50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL4321392
HCT-116	Cell lines	IC50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL4321392
HCT-116	Cell lines	IC50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL4321392
HCT-116	Cell lines	IC50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL4321392
HCT-116	Cell lines	IC50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL4321392
HCT-116	Cell lines	IC50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL3611202
HCT-116	Cell lines	IC50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL3611202
HCT-116	Cell lines	IC50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL4254165
HCT-116	Cell lines	IC50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL4262062
HCT-116	Cell lines	IC50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL4341188
HCT-116	Cell lines	IC50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL5146643
HCT-116	Cell lines	IC50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL5147084
HCT-116	Cell lines	IC50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL5551412
HCT-116	Cell lines	IC50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL5614469
HCT-116	Cell lines	IC50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL6073913

Other measurements 15

Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.

Target	Class	Type	Value (nM)	pX	Organism	Assay
HCT-116	Cell lines	Activity	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL4321399
HCT-116	Cell lines	Activity	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL4321399
HCT-116	Cell lines	Activity	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL4321399
HCT-116	Cell lines	Activity	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL4321399
HCT-116	Cell lines	Activity	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL4321399
HCT-116	Cell lines	Activity	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL4321399
HCT-116	Cell lines	GI50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL1963874
HCT-116	Cell lines	GI50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL1963874
HCT-116	Cell lines	GI50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL1963874
HCT-116	Cell lines	Activity	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL6109693
HCT-116	Cell lines	Activity	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL5255812
HCT-116	Cell lines	Activity	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL3748516
HCT-116	Cell lines	Activity	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL3606734
HCT-116	Cell lines	Activity	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL3606943
HCT-116	Cell lines	Inhibition	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL6073911

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