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PsychedeliaDokholyan Laboratory
TargetUnclassified

Glutaminase kidney isoform, mitochondrial

Matched no rule. Shown as-is rather than assigned a class by guesswork. Values below are reported as measured; because this is not a molecular target, they are not treated as affinities anywhere on this site.

Measurements
12
Compounds
12
Binding constants
0
Median pX
—

I · Identity

What this target is

Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.

Protein

GLSK_HUMANGLSHomo sapiens

Glutaminase kidney isoform, mitochondrial

Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate, the main excitatory neurotransmitter in the brain30239721,30575854,30970188
Lacks catalytic activity

Quoted from UniProt’s FUNCTION annotation for O94925 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

PartnerCombinedExperimentDatabaseText mining
GLUD10.9880.0000.9560.736
GLUL0.9870.0000.9560.716
GLUD20.9760.0000.9560.479
ALDH18A10.9730.0000.9620.283
GAD10.9480.0000.9000.400
GAD20.9420.0000.9000.332
PPAT0.9370.0000.9000.401
GFPT10.9370.0000.9000.376
GFPT20.9340.0000.9000.369
CAD0.9300.0000.9000.322

Where it sits in the cell

  • Mitochondria

Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.

UniProt, curated Mitochondrion · Cytoplasm, cytosol · Mitochondrion matrix

Expression by cell type

Single cell type RNA, the 3 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.

  • Renal connecting tubule cells846.8 nCPM
  • Podocytes820.8 nCPM
  • Renal collecting duct principal cells812.4 nCPM

Expression by tissue

The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.

  • kidney144.3 nTPM

II · Anatomy

Where the gene is transcribed

The same two atlases the compound plates use, asked about this gene alone. Brain on the left, peripheral and autonomic tissues on the right.

Brain

cerebral cortex — 78.5 nTPM, from GLScerebellum — 71.9 nTPM, from GLShippocampal formation — 35.0 nTPM, from GLSamygdala — 31.7 nTPM, from GLShypothalamus — 36.8 nTPM, from GLSthalamus — no resolved target expressed herebasal ganglia — 38.8 nTPM, from GLSmedulla oblongata — no resolved target expressed here

basal ganglia: drawn as the caudate nucleus, putamen and globus pallidus.

Measured but not drawn — this anatomogram has no outline for them: midbrain 30.2, retina 22.6, spinal cord 19.2, pituitary gland 16.1.

Body

heart — 26.8 nTPM, from GLSsmooth muscle — 24.6 nTPM, from GLSlung — 36.5 nTPM, from GLSliver — 8.1 nTPM, from GLSkidney — 144.3 nTPM, from GLSstomach — 15.0 nTPM, from GLSduodenum — 57.8 nTPM, from GLSsmall intestine — 62.3 nTPM, from GLScolon — 21.7 nTPM, from GLSadrenal gland — 65.9 nTPM, from GLSthyroid gland — 29.7 nTPM, from GLSpancreas — 30.3 nTPM, from GLSurinary bladder — 26.4 nTPM, from GLSskeletal muscle — 13.4 nTPM, from GLSspleen — 34.0 nTPM, from GLSsalivary gland — 15.3 nTPM, from GLS
0144 nTPM

Square-root ramp · shared scale across both plates

Shading is transcript level — not affinity, and not affinity combined with expression. Outlined but unshaded organs hold none of GLS transcript above the atlas’s detection threshold. Anatomy from EMBL-EBI Anatomogram (Apache License 2.0); regions identified by Uberon (uberon.org), CC BY 3.0.

Brain · 10

  • cerebral cortex78.5 nTPM
  • cerebellum71.9 nTPM
  • basal ganglia38.8 nTPM
  • hypothalamus36.8 nTPM
  • hippocampal formation35.0 nTPM
  • amygdala31.7 nTPM
  • midbrain30.2 nTPM
  • retina22.6 nTPM
  • spinal cord19.2 nTPM
  • pituitary gland16.1 nTPM

Peripheral and autonomic · 16

  • kidney144.3 nTPM
  • adrenal gland65.9 nTPM
  • small intestine62.3 nTPM
  • duodenum57.8 nTPM
  • lung36.5 nTPM
  • spleen34.0 nTPM
  • pancreas30.3 nTPM
  • thyroid gland29.7 nTPM
  • heart muscle26.8 nTPM
  • urinary bladder26.4 nTPM
  • smooth muscle24.6 nTPM
  • colon21.7 nTPM
  • salivary gland15.3 nTPM
  • stomach 115.0 nTPM
  • skeletal muscle13.4 nTPM
  • liver8.1 nTPM

Transcript is not protein. These are RNA levels for GLS, shaded on √nTPM so that a three-order range stays legible — on a linear ramp every region but the strongest would read as blank, which looks like absence rather than less. A region carrying no shading is one the atlas reports no consensus value for, not one where the gene is silent. And a gene being transcribed somewhere is not evidence that any compound reaches it. Human Protein Atlas, RNA expression, nTPM (normalized transcripts per million), consensus tissue dataset.

IV · Evidence

Every measurement at this target

Each row links to the ChEMBL assay it came from.

Functional readouts 12

IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.

TargetClassTypeValue (nM)pXOrganismAssay
Glutaminase kidney isoform, mitochondrialUnclassifiedPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL2114738
Glutaminase kidney isoform, mitochondrialUnclassifiedPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL2114738
Glutaminase kidney isoform, mitochondrialUnclassifiedPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL2114738
Glutaminase kidney isoform, mitochondrialUnclassifiedPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL2114738
Glutaminase kidney isoform, mitochondrialUnclassifiedPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL2114738
Glutaminase kidney isoform, mitochondrialUnclassifiedPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL2114738
Glutaminase kidney isoform, mitochondrialUnclassifiedPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL2114738
Glutaminase kidney isoform, mitochondrialUnclassifiedPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL2114738
Glutaminase kidney isoform, mitochondrialUnclassifiedPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL2114738
Glutaminase kidney isoform, mitochondrialUnclassifiedPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL2114738
Glutaminase kidney isoform, mitochondrialUnclassifiedPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL2114738
Glutaminase kidney isoform, mitochondrialUnclassifiedPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL2114738
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