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PsychedeliaDokholyan Laboratory
TargetUnclassified

DNA dC->dU-editing enzyme APOBEC-3G

Matched no rule. Shown as-is rather than assigned a class by guesswork. Values below are reported as measured; because this is not a molecular target, they are not treated as affinities anywhere on this site.

Measurements
2
Compounds
2
Binding constants
0
Median pX
—

I · Identity

What this target is

Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.

Protein

ABC3G_HUMANAPOBEC3GHomo sapiens

DNA dC->dU-editing enzyme APOBEC-3G

DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms12808465,16527742,17121840,18288108,18849968,19153609,21123384,22791714,25542899. Exhibits potent antiviral activity against Vif-deficient HIV-112167863,12859895,14557625,20219927,21835787,22807680,22915799,23097438,23152537,31397674. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA12808465,12808466,12809610,12970355,14528300,22807680. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells12808465,12808466,12809610,12970355,14528300. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA12808465,12809610,12970355,14528300. Exhibits antiviral activity also against simian immunodeficiency viruses (SIVs), hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV)15031497,16378963,18448976,19458006,20335265. May inhibit the mobility of LTR and non-LTR retrotransposons16527742

Quoted from UniProt’s FUNCTION annotation for Q9HC16 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

PartnerCombinedExperimentDatabaseText mining
CUL50.9840.0000.6500.955
CBFB0.9570.8200.0000.773
CDA0.9450.0000.0000.944
BST20.9430.0000.0000.939
ELOB0.9380.0000.6500.813
APOBEC3F0.9330.2920.7200.166
TRIM50.9290.0000.0000.920
HDAC60.9180.2920.0000.887
ELOC0.8940.0000.6500.705
RNF70.8910.2920.6500.584

Where it sits in the cell

  • Nucleoplasm
  • Cytosol

Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.

UniProt, curated Cytoplasm · Nucleus · Cytoplasm, P-body

Expression by cell type

Single cell type RNA, the 9 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.

  • NK-cells166.4 nCPM
  • T-cells103.7 nCPM
  • Plasma cells81.9 nCPM
  • Sertoli cells60.8 nCPM
  • Early spermatids49.6 nCPM
  • Innate lymphoid cells45.7 nCPM
  • Megakaryocytes43.3 nCPM
  • B-cells40 nCPM
  • Hofbauer cells39.8 nCPM

Expression by tissue

The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.

  • lymphoid tissue43 nTPM

II · Anatomy

Where the gene is transcribed

The same two atlases the compound plates use, asked about this gene alone. Brain on the left, peripheral and autonomic tissues on the right.

Brain

cerebral cortex — 1.6 nTPM, from APOBEC3Gcerebellum — 0.6 nTPM, from APOBEC3Ghippocampal formation — 2.6 nTPM, from APOBEC3Gamygdala — 2.7 nTPM, from APOBEC3Ghypothalamus — 2.4 nTPM, from APOBEC3Gthalamus — no resolved target expressed herebasal ganglia — 2.4 nTPM, from APOBEC3Gmedulla oblongata — no resolved target expressed here

basal ganglia: drawn as the caudate nucleus, putamen and globus pallidus.

Measured but not drawn — this anatomogram has no outline for them: spinal cord 4.4, pituitary gland 3.7, midbrain 3.6, retina 1.3.

Body

heart — 4.0 nTPM, from APOBEC3Gsmooth muscle — 9.0 nTPM, from APOBEC3Glung — 13.7 nTPM, from APOBEC3Gliver — 5.3 nTPM, from APOBEC3Gkidney — 4.3 nTPM, from APOBEC3Gstomach — 9.4 nTPM, from APOBEC3Gduodenum — 5.2 nTPM, from APOBEC3Gsmall intestine — 10.0 nTPM, from APOBEC3Gcolon — 7.1 nTPM, from APOBEC3Gadrenal gland — 8.6 nTPM, from APOBEC3Gthyroid gland — 5.5 nTPM, from APOBEC3Gpancreas — 1.9 nTPM, from APOBEC3Gurinary bladder — 14.7 nTPM, from APOBEC3Gskeletal muscle — 1.1 nTPM, from APOBEC3Gspleen — 28.7 nTPM, from APOBEC3Gsalivary gland — 8.0 nTPM, from APOBEC3G
029 nTPM

Square-root ramp · shared scale across both plates

Shading is transcript level — not affinity, and not affinity combined with expression. Outlined but unshaded organs hold none of APOBEC3G transcript above the atlas’s detection threshold. Anatomy from EMBL-EBI Anatomogram (Apache License 2.0); regions identified by Uberon (uberon.org), CC BY 3.0.

Brain · 10

  • spinal cord4.4 nTPM
  • pituitary gland3.7 nTPM
  • midbrain3.6 nTPM
  • amygdala2.7 nTPM
  • hippocampal formation2.6 nTPM
  • hypothalamus2.4 nTPM
  • basal ganglia2.4 nTPM
  • cerebral cortex1.6 nTPM
  • retina1.3 nTPM
  • cerebellum0.6 nTPM

Peripheral and autonomic · 16

  • spleen28.7 nTPM
  • urinary bladder14.7 nTPM
  • lung13.7 nTPM
  • small intestine10.0 nTPM
  • stomach 19.4 nTPM
  • smooth muscle9.0 nTPM
  • adrenal gland8.6 nTPM
  • salivary gland8.0 nTPM
  • colon7.1 nTPM
  • thyroid gland5.5 nTPM
  • liver5.3 nTPM
  • duodenum5.2 nTPM
  • kidney4.3 nTPM
  • heart muscle4.0 nTPM
  • pancreas1.9 nTPM
  • skeletal muscle1.1 nTPM

Transcript is not protein. These are RNA levels for APOBEC3G, shaded on √nTPM so that a three-order range stays legible — on a linear ramp every region but the strongest would read as blank, which looks like absence rather than less. A region carrying no shading is one the atlas reports no consensus value for, not one where the gene is silent. And a gene being transcribed somewhere is not evidence that any compound reaches it. Human Protein Atlas, RNA expression, nTPM (normalized transcripts per million), consensus tissue dataset.

IV · Evidence

Every measurement at this target

Each row links to the ChEMBL assay it came from.

Functional readouts 2

IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.

TargetClassTypeValue (nM)pXOrganismAssay
DNA dC->dU-editing enzyme APOBEC-3GUnclassifiedPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1794342
DNA dC->dU-editing enzyme APOBEC-3GUnclassifiedPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1794342
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