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TargetUnclassified

Cytochrome b5

Matched no rule. Shown as-is rather than assigned a class by guesswork. Values below are reported as measured; because this is not a molecular target, they are not treated as affinities anywhere on this site.

Measurements
1
Compounds
1
Binding constants
0
Median pX
—

I · Identity

What this target is

Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.

Protein

CYB5_HUMANCYB5AHomo sapiens

Cytochrome b5

Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases

Quoted from UniProt’s FUNCTION annotation for P00167 (reviewed).

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

PartnerCombinedExperimentDatabaseText mining
CYB5R30.9990.2540.7500.999
POR0.9970.0990.0000.997
CYCS0.9960.2950.0000.995
CYB5RL0.9940.1080.0000.993
CYB5R10.9930.1110.0000.992
CYB5R20.9930.1110.0000.991
MB0.9880.0000.0000.988
SCD0.9810.0950.0000.979
CYP17A10.9790.0710.0000.978
CYB5R40.9690.0950.0000.965

Where it sits in the cell

  • Vesicles
  • Cytosol

Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.

UniProt, curated Endoplasmic reticulum membrane · Microsome membrane · Cytoplasm

Expression by cell type

Single cell type RNA, the 6 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.

  • Hepatocytes3,986.6 nCPM
  • Alveolar cells type 22,211.1 nCPM
  • Transitional alveolar cells1,918.9 nCPM
  • Enterocytes1,661 nCPM
  • Breast lactating cells1,374 nCPM
  • Urothelial cells1,103.3 nCPM

Expression by tissue

The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.

  • liver2,306.7 nTPM
  • kidney828 nTPM

IV · Evidence

Every measurement at this target

Each row links to the ChEMBL assay it came from.

Other measurements 1

Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.

TargetClassTypeValue (nM)pXOrganismAssay
Cytochrome b5UnclassifiedDrug metabolism— no normalized value— value does not convert to pXHomo sapiensCHEMBL3538988