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PsychedeliaDokholyan Laboratory
TargetUnclassified

Chromobox protein homolog 1

Matched no rule. Shown as-is rather than assigned a class by guesswork. Values below are reported as measured; because this is not a molecular target, they are not treated as affinities anywhere on this site.

Measurements
10
Compounds
10
Binding constants
0
Median pX
—

I · Identity

What this target is

Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.

Protein

CBX1_HUMANCBX1Homo sapiens

Chromobox protein homolog 1

Component of heterochromatin, which recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression41094145. Also recognizes and binds histone H1.4 methylated at 'Lys-26' (H1.4K26me)16127177. Excluded from chromatin when histone H1.4 is Simultaneously methylated at Lys-26 (H1.4K26me) and phosphorylated at Ser-27 (H1.4S27Ph)16127177. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane (By similarity)

Quoted from UniProt’s FUNCTION annotation for P83916 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

PartnerCombinedExperimentDatabaseText mining
H3C130.9990.9370.5000.973
H3C120.9990.9740.5000.976
H3-20.9980.9370.0000.973
H3-40.9980.9610.0000.973
H3-3B0.9980.9350.0000.976
H3-50.9980.9270.0000.973
RING10.9910.2360.0000.989
BMI10.9910.0670.0000.991
COMMD3-BMI10.9910.0670.0000.991
SUV39H10.9900.7770.0000.959

Where it sits in the cell

  • Nucleoplasm
  • Nuclear bodies

Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.

UniProt, curated Nucleus

Expression by cell type

Single cell type RNA, the 2 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.

  • Early primary spermatocytes463.2 nCPM
  • Differentiating spermatogonia245.3 nCPM

II · Anatomy

Where the gene is transcribed

The same two atlases the compound plates use, asked about this gene alone. Brain on the left, peripheral and autonomic tissues on the right.

Brain

cerebral cortex — 68.1 nTPM, from CBX1cerebellum — 68.5 nTPM, from CBX1hippocampal formation — 63.1 nTPM, from CBX1amygdala — 72.1 nTPM, from CBX1hypothalamus — 62.3 nTPM, from CBX1thalamus — no resolved target expressed herebasal ganglia — 62.5 nTPM, from CBX1medulla oblongata — no resolved target expressed here

basal ganglia: drawn as the caudate nucleus, putamen and globus pallidus.

Measured but not drawn — this anatomogram has no outline for them: spinal cord 82.0, midbrain 61.9, retina 55.1, pituitary gland 33.6.

Body

heart — 30.1 nTPM, from CBX1smooth muscle — 51.9 nTPM, from CBX1lung — 25.4 nTPM, from CBX1liver — 20.2 nTPM, from CBX1kidney — 36.0 nTPM, from CBX1stomach — 26.1 nTPM, from CBX1duodenum — 17.9 nTPM, from CBX1small intestine — 23.5 nTPM, from CBX1colon — 39.3 nTPM, from CBX1adrenal gland — 29.6 nTPM, from CBX1thyroid gland — 37.0 nTPM, from CBX1pancreas — 21.7 nTPM, from CBX1urinary bladder — 36.7 nTPM, from CBX1skeletal muscle — 64.1 nTPM, from CBX1spleen — 31.8 nTPM, from CBX1salivary gland — 28.8 nTPM, from CBX1
082 nTPM

Square-root ramp · shared scale across both plates

Shading is transcript level — not affinity, and not affinity combined with expression. Outlined but unshaded organs hold none of CBX1 transcript above the atlas’s detection threshold. Anatomy from EMBL-EBI Anatomogram (Apache License 2.0); regions identified by Uberon (uberon.org), CC BY 3.0.

Brain · 10

  • spinal cord82.0 nTPM
  • amygdala72.1 nTPM
  • cerebellum68.5 nTPM
  • cerebral cortex68.1 nTPM
  • hippocampal formation63.1 nTPM
  • basal ganglia62.5 nTPM
  • hypothalamus62.3 nTPM
  • midbrain61.9 nTPM
  • retina55.1 nTPM
  • pituitary gland33.6 nTPM

Peripheral and autonomic · 16

  • skeletal muscle64.1 nTPM
  • smooth muscle51.9 nTPM
  • colon39.3 nTPM
  • thyroid gland37.0 nTPM
  • urinary bladder36.7 nTPM
  • kidney36.0 nTPM
  • spleen31.8 nTPM
  • heart muscle30.1 nTPM
  • adrenal gland29.6 nTPM
  • salivary gland28.8 nTPM
  • stomach 126.1 nTPM
  • lung25.4 nTPM
  • small intestine23.5 nTPM
  • pancreas21.7 nTPM
  • liver20.2 nTPM
  • duodenum17.9 nTPM

Transcript is not protein. These are RNA levels for CBX1, shaded on √nTPM so that a three-order range stays legible — on a linear ramp every region but the strongest would read as blank, which looks like absence rather than less. A region carrying no shading is one the atlas reports no consensus value for, not one where the gene is silent. And a gene being transcribed somewhere is not evidence that any compound reaches it. Human Protein Atlas, RNA expression, nTPM (normalized transcripts per million), consensus tissue dataset.

IV · Evidence

Every measurement at this target

Each row links to the ChEMBL assay it came from.

Functional readouts 10

IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.

TargetClassTypeValue (nM)pXOrganismAssay
Chromobox protein homolog 1UnclassifiedPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1738610
Chromobox protein homolog 1UnclassifiedPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1738610
Chromobox protein homolog 1UnclassifiedPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1738610
Chromobox protein homolog 1UnclassifiedPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1738610
Chromobox protein homolog 1UnclassifiedPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1738610
Chromobox protein homolog 1UnclassifiedPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1794401
Chromobox protein homolog 1UnclassifiedPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1794401
Chromobox protein homolog 1UnclassifiedPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1794401
Chromobox protein homolog 1UnclassifiedPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1794401
Chromobox protein homolog 1UnclassifiedPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1794401
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