Bromodomain adjacent to zinc finger domain protein 2B
Matched no rule. Shown as-is rather than assigned a class by guesswork. Values below are reported as measured; because this is not a molecular target, they are not treated as affinities anywhere on this site.
- Measurements
- 5
- Compounds
- 5
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
Bromodomain adjacent to zinc finger domain protein 2B
Regulatory subunit of the ATP-dependent BRF-1 and BRF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair28801535. Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template28801535. The BRF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the BRF-5 ISWI chromatin remodeling complex28801535. Chromatin reader protein, which may play a role in transcriptional regulation via interaction with ISWI (By similarity)10662543. Involved in positively modulating the rate of age-related behavioral deterioration (By similarity). Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with histone methyltransferase EHMT1 (By similarity)
Quoted from UniProt’s FUNCTION annotation for Q9UIF8 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
| Partner | Combined | Experiment | Database | Text mining |
|---|---|---|---|---|
| ZNF215 | 0.942 | 0.061 | 0.000 | 0.941 |
| SMARCA1 | 0.931 | 0.515 | 0.000 | 0.862 |
| SMARCA5 | 0.923 | 0.515 | 0.000 | 0.844 |
| ZNF214 | 0.807 | 0.061 | 0.000 | 0.803 |
| WDSUB1 | 0.805 | 0.000 | 0.000 | 0.474 |
| POLE3 | 0.749 | 0.423 | 0.000 | 0.583 |
| ATRX | 0.629 | 0.181 | 0.000 | 0.500 |
| BAZ1B | 0.599 | 0.000 | 0.000 | 0.588 |
| CECR2 | 0.562 | 0.070 | 0.000 | 0.541 |
| CHRAC1 | 0.546 | 0.114 | 0.000 | 0.501 |
Where it sits in the cell
- Nucleoplasm
- Cytosoladditional
Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.
UniProt, curated Nucleus
Expression by cell type
Single cell type RNA, the 1 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Neutrophils1,302.6 nCPM
II · Anatomy
Where the gene is transcribed
The same two atlases the compound plates use, asked about this gene alone. Brain on the left, peripheral and autonomic tissues on the right.
Brain
basal ganglia: drawn as the caudate nucleus, putamen and globus pallidus.
Measured but not drawn — this anatomogram has no outline for them: retina 48.2, pituitary gland 16.5, spinal cord 16.1, midbrain 12.8.
Body
Square-root ramp · shared scale across both plates
Shading is transcript level — not affinity, and not affinity combined with expression. Outlined but unshaded organs hold none of BAZ2B transcript above the atlas’s detection threshold. Anatomy from EMBL-EBI Anatomogram (Apache License 2.0); regions identified by Uberon (uberon.org), CC BY 3.0.
Brain · 10
- retina48.2 nTPM
- cerebral cortex19.6 nTPM
- cerebellum17.7 nTPM
- pituitary gland16.5 nTPM
- spinal cord16.1 nTPM
- midbrain12.8 nTPM
- basal ganglia11.9 nTPM
- hippocampal formation11.8 nTPM
- amygdala11.7 nTPM
- hypothalamus9.8 nTPM
Peripheral and autonomic · 16
- thyroid gland23.7 nTPM
- lung23.2 nTPM
- adrenal gland22.4 nTPM
- smooth muscle21.8 nTPM
- salivary gland21.8 nTPM
- spleen19.7 nTPM
- urinary bladder19.5 nTPM
- pancreas18.2 nTPM
- skeletal muscle17.5 nTPM
- small intestine17.4 nTPM
- heart muscle17.2 nTPM
- colon17.1 nTPM
- kidney16.1 nTPM
- duodenum16.1 nTPM
- stomach 116.0 nTPM
- liver15.6 nTPM
Transcript is not protein. These are RNA levels for BAZ2B, shaded on √nTPM so that a three-order range stays legible — on a linear ramp every region but the strongest would read as blank, which looks like absence rather than less. A region carrying no shading is one the atlas reports no consensus value for, not one where the gene is silent. And a gene being transcribed somewhere is not evidence that any compound reaches it. Human Protein Atlas, RNA expression, nTPM (normalized transcripts per million), consensus tissue dataset.
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Functional readouts 5
IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Bromodomain adjacent to zinc finger domain protein 2B | Unclassified | Potency | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1738312 |
| Bromodomain adjacent to zinc finger domain protein 2B | Unclassified | Potency | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1738312 |
| Bromodomain adjacent to zinc finger domain protein 2B | Unclassified | Potency | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1738312 |
| Bromodomain adjacent to zinc finger domain protein 2B | Unclassified | Potency | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1738312 |
| Bromodomain adjacent to zinc finger domain protein 2B | Unclassified | Potency | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1738312 |