Breast cancer type 1 susceptibility protein
Matched no rule. Shown as-is rather than assigned a class by guesswork. Values below are reported as measured; because this is not a molecular target, they are not treated as affinities anywhere on this site.
- Measurements
- 1
- Compounds
- 1
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
Breast cancer type 1 susceptibility protein
E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage10500182,12887909,12890688,14976165,16818604,17525340,19261748. It is unclear whether it also mediates the formation of other types of polyubiquitin chains12890688. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability12890688,14976165,20351172. Regulates centrosomal microtubule nucleation18056443. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle10724175,11836499,12183412,19261748. Required for FANCD2 targeting to sites of DNA damage12887909. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation16326698. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks19369211. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP816818604. Acts as a transcriptional activator20160719
Quoted from UniProt’s FUNCTION annotation for P38398 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
Where it sits in the cell
- Nuclear bodies
- Nucleoplasmadditional
Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.
UniProt, curated Nucleus · Chromosome · Cytoplasm
Expression by cell type
Single cell type RNA, the 5 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Early primary spermatocytes211.2 nCPM
- Erythrocyte progenitors157.1 nCPM
- Megakaryocyte progenitors147.3 nCPM
- Monocyte progenitors129.9 nCPM
- Neutrophil progenitors96.5 nCPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Functional readouts 1
IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Breast cancer type 1 susceptibility protein | Unclassified | Potency | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1613817 |