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PsychedeliaDokholyan Laboratory
TargetUnclassified

ATPase family AAA domain-containing protein 5

Matched no rule. Shown as-is rather than assigned a class by guesswork. Values below are reported as measured; because this is not a molecular target, they are not treated as affinities anywhere on this site.

Measurements
8
Compounds
7
Binding constants
0
Median pX
—

I · Identity

What this target is

Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.

Protein

ATAD5_HUMANATAD5Homo sapiens

ATPase family AAA domain-containing protein 5

Has an important role in DNA replication and in maintaining genome integrity during replication stress15983387,19755857. Involved in a RAD9A-related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis15983387. Modulates the RAD9A interaction with BCL2 and thereby induces DNA damage-induced apoptosis15983387. Promotes PCNA deubiquitination by recruiting the ubiquitin-specific protease 1 (USP1) and WDR48 thereby down-regulating the error-prone damage bypass pathway20147293. As component of the ATAD5 RFC-like complex, regulates the function of the DNA polymerase processivity factor PCNA by unloading the ring-shaped PCNA homotrimer from DNA after replication during the S phase of the cell cycle23277426,23937667. This seems to be dependent on its ATPase activity23277426. Plays important roles in restarting stalled replication forks under replication stress, by unloading the PCNA homotrimer from DNA and recruiting RAD51 possibly through an ATR-dependent manner31844045. Ultimately this enables replication fork regression, breakage, and eventual fork restart31844045. Both the PCNA unloading activity and the interaction with WDR48 are required to efficiently recruit RAD51 to stalled replication forks31844045. Promotes the generation of MUS81-mediated single-stranded DNA-associated breaks in response to replication stress, which is an alternative pathway to restart stalled/regressed replication forks31844045

Quoted from UniProt’s FUNCTION annotation for Q96QE3 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

PartnerCombinedExperimentDatabaseText mining
RFC20.9990.8480.0000.993
RFC40.9990.9730.9000.678
RFC50.9970.9550.0000.922
RFC30.9850.9410.0000.626
WDR480.9730.6250.0000.927
RAD170.9690.6210.0000.914
WDHD10.9550.5140.0000.705
RFC10.9450.0880.9000.387
BRD40.9410.8190.0000.685
PCNA0.9360.8790.0000.350

Where it sits in the cell

  • Nucleoplasm
  • Cytokinetic bridgeadditional
  • Centriolar satelliteadditional
  • Cytosoladditional

Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.

UniProt, curated Nucleus

Expression by cell type

Single cell type RNA, the 6 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.

  • Erythrocyte progenitors322.5 nCPM
  • Monocyte progenitors155.8 nCPM
  • Epicardial cells129.6 nCPM
  • Megakaryocyte progenitors119.7 nCPM
  • Early primary spermatocytes105.2 nCPM
  • Neutrophil progenitors97.8 nCPM

Expression by tissue

The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.

  • bone marrow11.6 nTPM

II · Anatomy

Where the gene is transcribed

The same two atlases the compound plates use, asked about this gene alone. Brain on the left, peripheral and autonomic tissues on the right.

Brain

cerebral cortex — 0.5 nTPM, from ATAD5cerebellum — 1.7 nTPM, from ATAD5hippocampal formation — 0.3 nTPM, from ATAD5amygdala — 0.3 nTPM, from ATAD5hypothalamus — 0.3 nTPM, from ATAD5thalamus — no resolved target expressed herebasal ganglia — 0.4 nTPM, from ATAD5medulla oblongata — no resolved target expressed here

basal ganglia: drawn as the caudate nucleus, putamen and globus pallidus.

Measured but not drawn — this anatomogram has no outline for them: retina 2.3, pituitary gland 0.5, spinal cord 0.4, midbrain 0.3.

Body

heart — 0.3 nTPM, from ATAD5smooth muscle — 0.6 nTPM, from ATAD5lung — 0.7 nTPM, from ATAD5liver — 0.5 nTPM, from ATAD5kidney — 0.3 nTPM, from ATAD5stomach — 1.0 nTPM, from ATAD5duodenum — 1.3 nTPM, from ATAD5small intestine — 1.3 nTPM, from ATAD5colon — 1.1 nTPM, from ATAD5adrenal gland — 0.4 nTPM, from ATAD5thyroid gland — 0.5 nTPM, from ATAD5pancreas — 0.5 nTPM, from ATAD5urinary bladder — 0.5 nTPM, from ATAD5skeletal muscle — 0.4 nTPM, from ATAD5spleen — 1.3 nTPM, from ATAD5salivary gland — 0.7 nTPM, from ATAD5
02 nTPM

Square-root ramp · shared scale across both plates

Shading is transcript level — not affinity, and not affinity combined with expression. Outlined but unshaded organs hold none of ATAD5 transcript above the atlas’s detection threshold. Anatomy from EMBL-EBI Anatomogram (Apache License 2.0); regions identified by Uberon (uberon.org), CC BY 3.0.

Brain · 10

  • retina2.3 nTPM
  • cerebellum1.7 nTPM
  • cerebral cortex0.5 nTPM
  • pituitary gland0.5 nTPM
  • basal ganglia0.4 nTPM
  • spinal cord0.4 nTPM
  • hippocampal formation0.3 nTPM
  • amygdala0.3 nTPM
  • hypothalamus0.3 nTPM
  • midbrain0.3 nTPM

Peripheral and autonomic · 16

  • duodenum1.3 nTPM
  • small intestine1.3 nTPM
  • spleen1.3 nTPM
  • colon1.1 nTPM
  • stomach 11.0 nTPM
  • lung0.7 nTPM
  • salivary gland0.7 nTPM
  • smooth muscle0.6 nTPM
  • liver0.5 nTPM
  • thyroid gland0.5 nTPM
  • pancreas0.5 nTPM
  • urinary bladder0.5 nTPM
  • adrenal gland0.4 nTPM
  • skeletal muscle0.4 nTPM
  • heart muscle0.3 nTPM
  • kidney0.3 nTPM

Transcript is not protein. These are RNA levels for ATAD5, shaded on √nTPM so that a three-order range stays legible — on a linear ramp every region but the strongest would read as blank, which looks like absence rather than less. A region carrying no shading is one the atlas reports no consensus value for, not one where the gene is silent. And a gene being transcribed somewhere is not evidence that any compound reaches it. Human Protein Atlas, RNA expression, nTPM (normalized transcripts per million), consensus tissue dataset.

IV · Evidence

Every measurement at this target

Each row links to the ChEMBL assay it came from.

Functional readouts 8

IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.

TargetClassTypeValue (nM)pXOrganismAssay
ATPase family AAA domain-containing protein 5UnclassifiedPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1738588
ATPase family AAA domain-containing protein 5UnclassifiedPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1738588
ATPase family AAA domain-containing protein 5UnclassifiedPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1738675
ATPase family AAA domain-containing protein 5UnclassifiedPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1738675
ATPase family AAA domain-containing protein 5UnclassifiedPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1738675
ATPase family AAA domain-containing protein 5UnclassifiedPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1737868
ATPase family AAA domain-containing protein 5UnclassifiedPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1737868
ATPase family AAA domain-containing protein 5UnclassifiedPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1738317
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