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PsychedeliaDokholyan Laboratory
TargetUnclassified

Ataxin-2

Matched no rule. Shown as-is rather than assigned a class by guesswork. Values below are reported as measured; because this is not a molecular target, they are not treated as affinities anywhere on this site.

Measurements
10
Compounds
7
Binding constants
0
Median pX
—

I · Identity

What this target is

Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.

Protein

ATX2_HUMANATXN2Homo sapiens

Ataxin-2

Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane

Quoted from UniProt’s FUNCTION annotation for Q99700 (reviewed).

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

PartnerCombinedExperimentDatabaseText mining
PABPC10.9980.9860.0000.875
ITPR10.9960.0000.9000.969
RBFOX10.9950.1790.0000.995
ATXN30.9930.0000.9000.939
DDX60.9930.8960.0000.933
TARDBP0.9920.5070.0000.984
LSM120.9850.9490.0000.715
ATXN10.9690.3130.0000.955
ATXN3L0.9610.0000.9000.635
ATXN2L0.9530.4420.9000.187

Where it sits in the cell

  • Cytosol

Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.

UniProt, curated Cytoplasm

II · Anatomy

Where the gene is transcribed

The same two atlases the compound plates use, asked about this gene alone. Brain on the left, peripheral and autonomic tissues on the right.

Brain

cerebral cortex — 26.3 nTPM, from ATXN2cerebellum — 28.2 nTPM, from ATXN2hippocampal formation — 22.7 nTPM, from ATXN2amygdala — 21.8 nTPM, from ATXN2hypothalamus — 24.5 nTPM, from ATXN2thalamus — no resolved target expressed herebasal ganglia — 21.8 nTPM, from ATXN2medulla oblongata — no resolved target expressed here

basal ganglia: drawn as the caudate nucleus, putamen and globus pallidus.

Measured but not drawn — this anatomogram has no outline for them: spinal cord 27.6, midbrain 24.2, pituitary gland 21.6, retina 14.6.

Body

heart — 22.3 nTPM, from ATXN2smooth muscle — 17.1 nTPM, from ATXN2lung — 18.4 nTPM, from ATXN2liver — 19.6 nTPM, from ATXN2kidney — 16.8 nTPM, from ATXN2stomach — 16.1 nTPM, from ATXN2duodenum — 10.5 nTPM, from ATXN2small intestine — 14.3 nTPM, from ATXN2colon — 22.4 nTPM, from ATXN2adrenal gland — 24.4 nTPM, from ATXN2thyroid gland — 16.2 nTPM, from ATXN2pancreas — 13.3 nTPM, from ATXN2urinary bladder — 19.6 nTPM, from ATXN2skeletal muscle — 26.5 nTPM, from ATXN2spleen — 13.5 nTPM, from ATXN2salivary gland — 14.4 nTPM, from ATXN2
028 nTPM

Square-root ramp · shared scale across both plates

Shading is transcript level — not affinity, and not affinity combined with expression. Outlined but unshaded organs hold none of ATXN2 transcript above the atlas’s detection threshold. Anatomy from EMBL-EBI Anatomogram (Apache License 2.0); regions identified by Uberon (uberon.org), CC BY 3.0.

Brain · 10

  • cerebellum28.2 nTPM
  • spinal cord27.6 nTPM
  • cerebral cortex26.3 nTPM
  • hypothalamus24.5 nTPM
  • midbrain24.2 nTPM
  • hippocampal formation22.7 nTPM
  • amygdala21.8 nTPM
  • basal ganglia21.8 nTPM
  • pituitary gland21.6 nTPM
  • retina14.6 nTPM

Peripheral and autonomic · 16

  • skeletal muscle26.5 nTPM
  • adrenal gland24.4 nTPM
  • colon22.4 nTPM
  • heart muscle22.3 nTPM
  • liver19.6 nTPM
  • urinary bladder19.6 nTPM
  • lung18.4 nTPM
  • smooth muscle17.1 nTPM
  • kidney16.8 nTPM
  • thyroid gland16.2 nTPM
  • stomach 116.1 nTPM
  • salivary gland14.4 nTPM
  • small intestine14.3 nTPM
  • spleen13.5 nTPM
  • pancreas13.3 nTPM
  • duodenum10.5 nTPM

Transcript is not protein. These are RNA levels for ATXN2, shaded on √nTPM so that a three-order range stays legible — on a linear ramp every region but the strongest would read as blank, which looks like absence rather than less. A region carrying no shading is one the atlas reports no consensus value for, not one where the gene is silent. And a gene being transcribed somewhere is not evidence that any compound reaches it. Human Protein Atlas, RNA expression, nTPM (normalized transcripts per million), consensus tissue dataset.

IV · Evidence

Every measurement at this target

Each row links to the ChEMBL assay it came from.

Functional readouts 10

IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.

TargetClassTypeValue (nM)pXOrganismAssay
Ataxin-2UnclassifiedPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1794367
Ataxin-2UnclassifiedPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1794367
Ataxin-2UnclassifiedPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1794367
Ataxin-2UnclassifiedPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1794367
Ataxin-2UnclassifiedPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL2114784
Ataxin-2UnclassifiedPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL2114784
Ataxin-2UnclassifiedPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL2114784
Ataxin-2UnclassifiedPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL2114784
Ataxin-2UnclassifiedPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL2114784
Ataxin-2UnclassifiedPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL2114784
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