Angiotensin-converting enzyme 2
Matched no rule. Shown as-is rather than assigned a class by guesswork. Values below are reported as measured; because this is not a molecular target, they are not treated as affinities anywhere on this site.
- Measurements
- 1
- Compounds
- 1
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
Angiotensin-converting enzyme 2
Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis27217402. Converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II10924499,10969042,11815627,14504186,19021774. Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin10969042,11815627. Also cleaves other biological peptides, such as apelins (apelin-13, [Pyr1]apelin-13, apelin-17, apelin-36), casomorphins (beta-casomorphin-7, neocasomorphin) and dynorphin A with high efficiency11815627,27217402,28293165. In addition, ACE2 C-terminus is homologous to collectrin and is responsible for the trafficking of the neutral amino acid transporter SL6A19 to the plasma membrane of gut epithelial cells via direct interaction, regulating its expression on the cell surface and its catalytic activity18424768,19185582
(Microbial infection) Acts as a receptor for human coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus NL63/HCoV-NL63
Non-functional as a carboxypeptidase
(Microbial infection) Non-functional as a receptor for human coronavirus SARS-CoV-2
Quoted from UniProt’s FUNCTION annotation for Q9BYF1 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
| Partner | Combined | Experiment | Database | Text mining |
|---|---|---|---|---|
| DPP4 | 0.999 | 0.000 | 0.900 | 0.995 |
| TMPRSS2 | 0.999 | 0.292 | 0.000 | 0.999 |
| AGT | 0.999 | 0.739 | 0.750 | 0.989 |
| SLC6A19 | 0.999 | 0.981 | 0.000 | 0.996 |
| SLC6A20 | 0.998 | 0.901 | 0.000 | 0.986 |
| AGTR1 | 0.996 | 0.000 | 0.000 | 0.996 |
| ERVW-1 | 0.994 | 0.000 | 0.000 | 0.994 |
| ERV3-1 | 0.992 | 0.000 | 0.000 | 0.992 |
| ERVFRD-1 | 0.992 | 0.000 | 0.000 | 0.992 |
| CLEC4M | 0.983 | 0.294 | 0.000 | 0.977 |
Where it sits in the cell
UniProt, curated Secreted · Cell membrane · Cytoplasm · Cell projection, cilium · Apical cell membrane
Expression by cell type
Single cell type RNA, the 5 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Enterocytes264.8 nCPM
- Vascular endothelial cells68 nCPM
- Proximal tubule cells54.4 nCPM
- Tuft cells34.6 nCPM
- Cholangiocytes29.6 nCPM
Expression by tissue
The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.
- intestine230.5 nTPM
- kidney82.4 nTPM
- gallbladder62.3 nTPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Functional readouts 1
IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Angiotensin-converting enzyme 2 | Unclassified | IC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5628764 |