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PsychedeliaDokholyan Laboratory
Plate 517 of 545Verified

Thymol

Also known as2-Isopropyl-5-methylphenol · 5-Methyl-2-(1-methylethyl)phenol · Thyme camphor · 5-Methyl-2-isopropylphenol · 6-Isopropyl-m-cresol · 3-p-Cymenol · m-Thymol · p-Cymen-3-ol

5-methyl-2-propan-2-ylphenol

PubChem CID
6989
Measurements
3
InChIKey
MGSRCZKZVOBKFT-UHFFFAOYSA-N

I · Summary

What is known

Published passages, each quoted whole and attributed to the database that published it. Two blocks are written here rather than quoted, and both say so where they stand: the synthesized summary at the top, which may draw only on the passages beneath it, and the history note, which cites the works it came from. Every claim in either carries a marker to its source.

What it is

  • Thymol is a phenol that is a natural monoterpene derivative of cymene. It has a role as a volatile oil component. It is a monoterpenoid and a member of phenols. It derives from a hydride of a p-cymene.

    ChEBI

  • The CIR Expert panel concludes Sodium p-Chloro-m-Cresol, p-Chloro-m-Cresol, Chlorothymol, m-Cresol, o-Cresol, Isopropyl Cresols, Thymol, o-Cymen-5-ol, Cavacrol are safe at concentrations up to 0.5% in cosmetics; however, the available data are insufficient to support the safety of p-Cresol and Mixed Cresols for use in cosmetic products.

    Cosmetic Ingredient Review (CIR)International Journal of Toxicology 25(Suppl. 1):29-127, 2006

  • A phenol obtained from thyme oil or other volatile oils. It is used as a stabilizer in pharmaceutic preparations. It has been used for its antiseptic, antibacterial, and antifungal actions, and was formerly used as a vermifuge. (Dorland, 28th ed)

    DrugBank

  • thymol has been reported in Acanthospermum australe, Humulus lupulus, and other organisms with data available.

    LOTUS - the natural products occurrence database

Recognized use

  • Anti-Infective Agents; Anti-Infective Agents, Local; Antifungal Agents

    Therapeutic Uses

    Hazardous Substances Data Bank (HSDB)National Library of Medicine's Medical Subject Headings online file (MeSH, 2014)

  • EXPL THER Thymol, a naturally occurring monocyclic phenolic compound derived from Thymus vulgaris (Lamiaceae), has been reported to exhibit anti-inflammatory property in vivo and vitro. However, the mechanism of thymol is not clear. The aim of the present study was to investigate the effects of thymol on allergic inflammation in OVA-induced mice asthma and explore its mechanism. The model of mouse asthma was established by the induction of OVA. Thymol was orally administered at a dose of 4, 8, and 16 mg/kg body weight 1hr before OVA challenge. At 24h after the last challenge, mice were sacrificed, and the data were collected by various experimental methods. The results revealed that pretreat…

    Therapeutic Uses

    Hazardous Substances Data Bank (HSDB)PMID 24785965Zhou E et al; Fitoterapia. 2014 Jul;96:131-7. doi: 10.1016/j.fitote.2014.04.016

  • EXPL THER Obesity has become a worldwide health problem. Most of the synthetic anti-obesity drugs have failed to manage the obesity due to either ineffectiveness or adverse effect. The research of prominent chemical constituents from herbal for the management of obesity has greatly increased. The main objective of the present study was intended to examine the effects of thymol in high-fat diet (HFD)-induced obesity in murine model. Male Wistar rats were fed HFD for 6 weeks to induce obesity. Thymol (14 mg/kg) administered orally twice a day to HFD-fed rats for 4 weeks. Alteration in body weight gain, visceral fat-pads weight and serum biochemical markers were assessed. At the end of study, r…

    Therapeutic Uses

    Hazardous Substances Data Bank (HSDB)PMID 24175857Haque MR et al; Toxicol Mech Methods. 2014 Feb;24(2):116-23. doi: 10.3109/15376516.2013.861888. Epub 2013 Dec 5

  • EXPL THER Mast cells play a critical role in inflammatory skin diseases through releasing proinflammatory mediators; however, few therapies directly target these cells. In 1878, the use of topical thymol, a now recognized potent agonist for transient receptor potential channels, was first described to treat eczema and psoriasis. /The objective was/ to determine the mechanisms through which thymol can alter skin inflammation. METHODS: /This study/ examined the effect of topical thymol on IgE-dependent responses using a mast cell-dependent passive cutaneous anaphylaxis (PCA) model, as well as in vitro-cultured mast cells. Thymol dose-dependently inhibited PCA when administered topically 24 hou…

    Therapeutic Uses

    Hazardous Substances Data Bank (HSDB)PMID 24486068Full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040322

  • Found in essential oils of Thymus vulgaris and Monardo punctata and other volatile oils; [Merck Index] A natural oil of the plant thyme; [Reference #1] Used as a biocide (mold and mildew), preservative (documents, art objects, and urine), stabilizer (trichloroethylene, chloroform, and halothane), flavoring agent, starting material for racemic menthol, antioxidant, lab reagent, disinfectant in oral hygiene products, antiseptic and antifungal in therapeutic lotions and ointments, and veterinary anthelmintic and antiseptic; [HSDB]

    Use Classification

    Haz-Map, Information on Hazardous Chemicals and Occupational DiseasesMerck Index - O'Neil MJ, Heckelman PE, Dobbelaar PH, Roman KJ (eds). The Merck Index, An Encyclopedia of Chemicals, Drugs, and Biologicals, 15th Ed. Cambridge, UK: The Royal Society of Chemistry, 2013.

  • For thymol (USEPA/OPP Pesticide Code: 080402) ACTIVE products with label matches. /SRP: Registered for use in the USA but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./

    Use Classification

    Hazardous Substances Data Bank (HSDB)National Pesticide Information Retrieval System's Database on Thymol (89-83-8). Available from, as of October 29, 2014: https://npirspublic.ceris.purdue.edu/ppis/

  • For destroying mold; preserving documents, art objects, and urine. Stabilizer (antioxidant) for trichloroethylene, halothane.

    Use Classification

    Hazardous Substances Data Bank (HSDB)O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Cambridge, UK: Royal Society of Chemistry, 2013., p. 1741

  • Active ingredient in pesticide products registered for use as animal repellants, fungicides/fungistats, medical disinfectants, tuberculocides, and virucides.

    Use Classification

    Hazardous Substances Data Bank (HSDB)USEPA/OPPTS; R.E.D. Facts Thymol (89-83-8). Reregistration Eligibility Decisions (REDs) Database. EPA-738-F-93-010. Sept 1993. Available from, as of Oct 31, 2014: https://www.epa.gov/pesticides/reregistration/status.htm

How it acts

  • The potent role of thymol, a natural compound, in modulation of macrophage activity was evaluated by determining all the sequential steps involved during phagocytosis. We found a significant increase in the proliferation of splenocytes in the presence of thymol and it proved to be a good mitogen. Uptake capacity of macrophages was enhanced due to increased membrane fluidity after treatment with thymol and it also increases lysosomal activity of macrophages. Data of superoxide anion generation revealed the involvement of thymol in the generation of respiratory burst as it potentiated this property of macrophages at a concentration of 150 uM. In the case of TNF-a, IL-1beta and PGE(2) a decreas…

    Hazardous Substances Data Bank (HSDB)PMID 24316253Chauhan AK et al; Int Immunopharmacol. 2014 Feb;18(2):340-6. doi: 10.1016/j.intimp.2013.11.025. Epub 2013 Dec 5.

Behavior carries the pharmacological classes and the acute-effect durations, with plasma half-life kept separate from duration of effect.

In the body

  • Aromatic herbs as feed additives in animal production are encountering growing interest, but data on the fate of the aromatic compounds from the plant in the animal body are very scarce. In the present study, thyme (Thymus vulgaris) herb consisting of leaves and flowers without stems was used as an ingredient in the diet for broilers. The herb was fed for 35 days to five groups of broilers (0, 0.1, 0.2, 0.3, and 1% w/w in the diet). Animal performance and the concentrations of the main essential oil component from thyme, thymol, were measured in gut contents, plasma and liver and muscle tissues using solid phase microextraction and gas chromatography/mass spectrometry. There were no differen…

    Absorption, Distribution and Excretion

    Hazardous Substances Data Bank (HSDB)PMID 24862829Haselmeyer A et al; J Sci Food Agric. 2014 May 24. doi: 10.1002/jsfa.6758.

  • Thymol is readily absorbed from the gastrointestinal tract following oral administration. It is essentially excreted in the urine within the first 24 hours after absorption.

    Absorption, Distribution and Excretion

    Hazardous Substances Data Bank (HSDB)Toxikologische Bewertung. Heidelberg, Berufsgenossenschaft der chemischen Industrie 259 38 p (2000)

  • Only small amounts of the absorbed substance undergo urinary excretion as hydroxylated compounds. Thymol is predominantly excreted unchanged and in the form of its glucuronide and sulfate conjugates.

    Metabolism/Metabolites

    Hazardous Substances Data Bank (HSDB)Toxikologische Bewertung. Heidelberg, Berufsgenossenschaft der chemischen Industrie 259 38 p (2000)

  • Substituted monophenols, thymol ... which occur in essential oils of plants, particularly thyme, are ... conjugated with glucuronic acid & sulfate.

    Metabolism/Metabolites

    Hazardous Substances Data Bank (HSDB)Parke, D. V. The Biochemistry of Foreign Compounds. Oxford: Pergamon Press, 1968., p. 147

  • Thymol has known human metabolites that include p-Cymene-2,3-diol, p-Cymen-8-en-3-ol, Thymoquinol, thymol sulfate, and thymol O-glucuronide.

    Metabolism/Metabolites

    NORMAN Suspect List ExchangeS73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560

History, discovery and cultural use

— Not in this archive. PubChem, ChEMBL and the Human Protein Atlas publish pharmacology, regulation and toxicology, and none of them publishes a heading for when Thymol was first made, by whom, or how it has been used. That is a gap in the databases this site reads and not a gap in the literature — the history of these compounds is written, at length and under peer review, in the works below. This site does not summarize them; it says where they are. Where a published passage above happens to touch origin or traditional use, it appears inside the entry that carries it.

Histories of this field

Scholarship on psychedelics generally, not on Thymol specifically. Whether any of these treats this compound is a question for the book, not for this page.

  • Mescaline: A Global History of the First Psychedelic

    Traces mescaline and the peyote and San Pedro cacti from pre-Columbian ritual use through nineteenth-century chemistry to twentieth-century psychiatry and the counterculture.

    Jay M. Mescaline: A Global History of the First Psychedelic. Yale University Press, New Haven and London; 2019. ISBN 9780300231076.

  • Expanding Mindscapes: A Global History of Psychedelicsopen access

    Essays on the international and cross-cultural history of psychedelic science, deliberately decentring the standard North American and European account.

    Dyck E, Elcock C, editors. Expanding Mindscapes: A Global History of Psychedelics. The MIT Press, Cambridge MA; 2023. ISBN 9780262546935 (paper), 9780262376891 (open access). doi:10.7551/mitpress/14417.001.0001.

  • Plants of the Gods: Their Sacred, Healing, and Hallucinogenic Powers

    Botany, ethnography and chemistry of the principal hallucinogenic plants, by the founder of modern ethnobotany and the chemist who first synthesized LSD.

    Schultes RE, Hofmann A, Rätsch C. Plants of the Gods: Their Sacred, Healing, and Hallucinogenic Powers. 2nd ed. Healing Arts Press, Rochester VT; 2001. ISBN 9780892819799.

  • Psychonauts: Drugs and the Making of the Modern Mind

    The tradition of scientific self-experimentation with psychoactive drugs, and its part in the emergence of psychology and of modernism.

    Jay M. Psychonauts: Drugs and the Making of the Modern Mind. Yale University Press, New Haven; 2023. ISBN 9780300257946.

  • Ancient Psychoactive Substances

    Archaeological and bioarchaeological evidence for psychoactive plant use across the ancient world.

    Fitzpatrick SM, editor. Ancient Psychoactive Substances. University Press of Florida, Gainesville; 2018. ISBN 9780813056708.

  • History and Current Status of Psychedelics and Entactogens for the Treatment of Psychiatric Disorders

    A chapter tracing psychedelic and entactogen research from earlier ritual use through the mid-century research period to current clinical trials.

    Stroud C, Posey Norris SM, Matney C, editors. History and Current Status of Psychedelics and Entactogens for the Treatment of Psychiatric Disorders. In: Exploring Psychedelics and Entactogens as Treatments for Psychiatric Disorders: Proceedings of a Workshop. National Academies Press, Washington DC; 2022. NBK587225.

    Workshop proceedings record what participants said; they are not a consensus statement of the National Academies.

  • Pharmacokinetic and Pharmacodynamic Aspects of Peyote and Mescaline: Clinical and Forensic Repercussions

    Peer-reviewed review covering the isolation, synthesis, pharmacology and ritual use of peyote and mescaline.

    Dinis-Oliveira RJ, Pereira CL, da Silva DD. Pharmacokinetic and Pharmacodynamic Aspects of Peyote and Mescaline: Clinical and Forensic Repercussions. Current Molecular Pharmacology 12(3):184–194; 2019. doi:10.2174/1874467211666181010154139.

Institutional archives

  • Heffter Research Institute Funds and coordinates clinical research on psilocybin, and keeps records of the studies it has supported since 1993. Sponsors the research it archives.
  • Multidisciplinary Association for Psychedelic Studies (MAPS) Sponsors clinical research, chiefly on MDMA-assisted therapy, and publishes an archive of historical and contemporary documents. A sponsor and an advocacy organization, not a disinterested archive; its clinical programme has a commercial arm.

The rest of this dossier

  • Affinity — 3 measurements in this archive, equilibrium constants kept apart from functional readouts.
  • Toxicology — 12 published passages, plus any assay in this archive bearing on toxicity.
  • Legal — no DEA record is held here — which is not a finding that this compound is uncontrolled.

Passages via PubChem descriptive sections, aggregating DrugBank, LiverTox, FDA, DEA, HSDB, EPA. Each is quoted whole and attributed to the database that published it. The only prose written here about Thymol is the history note, which says so on its face and carries a reference for every claim in it.

II · Identity

Structure and descriptors

Descriptors are computed here with RDKit from the structure PubChem returns — not from the archive's stored copy, so an edited local structure cannot reach this table.

2D structural depiction of Thymol
Depiction served by PubChem for CID 6989. Not redrawn here, so the picture and the identity come from the same record.
Formula
C10H14OR
Molecular weight
150.22g/molR
Exact mass
150.1045DaR
cLogP
2.82R
TPSA
20.2ŲR
H-bond donors
1R
H-bond acceptors
1R
Rotatable bonds
1R
Aromatic rings
1R
Heavy atoms
11R
Fraction sp³
0.400R
Formal charge
0R

Computed with RDKit 2025.09.2 from the SMILES returned by PubChem. Audit run 26/09/2026.

Bemis–Murcko scaffold

c1ccccc1

Shared with 2-Bromomescaline, 2-TOET, 2-TOM, 2,3,4,5-Tetramethoxyamphetamine, 2,4-dimethoxyamphetamine, 2,5-Dimethoxy-4-(2-fluoroethyl)amphetamine and 129 more. All families

III · Behavior

Behavioral summary

Class, mechanism, and the duration of acute effects — each quoted from the record or trial that publishes it. Duration of effects and plasma half-life are shown separately, because they are different quantities and diverge by a factor of three or four.

Classification

Duration of acute subjective effects

—

No controlled human trial reporting a duration for this compound is cited here. The archive holds no other record of one either. A duration is not inferred from a chemical relative.

Plasma elimination half-life

How fast the body clears the drug — not how long the effects last. The two diverge sharply: LSD is cleared with a half-life of about 2.6 h while its subjective effects run 8–12 h.

No half-life is published for this compound in the sources this site reads.

Primary pharmacological drivers

ChEMBL holds no curated mechanism-of-action record for this compound. The measured affinities below are the evidence this archive has for what it binds.

Mechanism, as published

Quoted verbatim from the database named after each passage, never summarized.

  • The potent role of thymol, a natural compound, in modulation of macrophage activity was evaluated by determining all the sequential steps involved during phagocytosis. We found a significant increase in the proliferation of splenocytes in the presence of thymol and it proved to be a good mitogen. Uptake capacity of macrophages was enhance…
    Hazardous Substances Data Bank (HSDB)PMID 24316253Chauhan AK et al; Int Immunopharmacol. 2014 Feb;18(2):340-6. doi: 10.1016/j.intimp.2013.11.025. Epub 2013 Dec 5.

IV · Clinical

Clinical description

Where this compound's substance class sits in ICD-11 and DSM-5-TR, and how much of the recorded literature speaks to each domain of a mental status examination.

No diagnostic chapter is shown for this compound. Either PubChem records no MeSH pharmacological class for it, or the class it records is not one of the substance classes ICD-11 gives a chapter to. Inferring a chapter from the compound’s name or its binding profile would be a diagnosis this archive is in no position to make.

How much has been written about each domain

The clinical domains, and how many of the records this archive holds for this compound say something under each. What the terms mean, and the word list behind every spoke, are set out in the method.

Affect0Mood0Perception0Cognition3Thought process0Thought content0Psychomotor activity1Insight and judgment0
This measures the literature, not the compound. Each spoke counts how many of the 13 records this archive holds for this compound say something under that domain — 3 at the widest ring. A long spoke means the subject has been written about, not that the effect is strong, and a spoke at the center means nothing here discusses it rather than that nothing happens. The terms behind each domain are listed in the method.
Cognition 3
matched on “concentrat” · in PMID 24316253; Toxicology: Cosmetic Ingredient Review (CIR); PMID 25038394
Psychomotor activity 1
matched on “hyperactiv” · in Toxicology: Hazardous Substances Data Bank (HSDB)

VI · Profile

Affinity rosette

The strongest measurement at each of 1 molecular targets. Cell-line and whole-organism screens are excluded here — they carry no affinity — and appear in the table below.

Transient receptor potential cation channel subfamily A member 1 — EC50 4.20 pXTransient recept…579
Fig. Radius is pX = −log₁₀(value in M), that is 9 − log₁₀(value in nM), computed from the normalized measurement. Hatched wedges are equilibrium binding constants (Ki, Kd); dashed outlines are functional readouts (IC₅₀, EC₅₀, AC₅₀, potency), which answer a different question and are not pooled with them. Rings mark whole pX units from 5 to 10, labeled every second ring in the gutter at the top. Where a target carries several measurements, the strongest is drawn.

VII · Toxicology

Toxicological profile

What has been measured, and what has been published — kept apart, and neither scored. There is no risk rating on this page; the archive once carried one, identical for every compound, produced by a stub.

Measured in this archive

Assays that bear on toxicity, drawn from the same ChEMBL records as everything else on this page. They are measurements of what a compound binds or does to cells — not verdicts about what it does to a person.

No hERG, cytochrome, cytotoxicity or transport measurement exists for Thymol in this archive.

Lethal-dose values — animal studies

These are not human doses. An LD50 is the dose killing half of a group of animals of one species by one route, and it is a poor predictor of human risk for these compounds. Each value is printed whole, with the species and route it was measured in, because a lethal dose separated from those two facts is worse than no figure at all. Nothing here supports inferring a safe dose for anyone.

  • LD50 Rat oral 980 mg/kg

    Hazardous Substances Data Bank (HSDB)Lewis, R.J. Sr. (ed) Sax's Dangerous Properties of Industrial Materials. 11th Edition. Wiley-Interscience, Wiley & Sons, Inc. Hoboken, NJ. 2004., p. 3463

  • LD50 Mouse oral 640 mg/kg

    Hazardous Substances Data Bank (HSDB)Lewis, R.J. Sr. (ed) Sax's Dangerous Properties of Industrial Materials. 11th Edition. Wiley-Interscience, Wiley & Sons, Inc. Hoboken, NJ. 2004., p. 3463

  • LD50 Mouse iv 100 mg/kg

    Hazardous Substances Data Bank (HSDB)Lewis, R.J. Sr. (ed) Sax's Dangerous Properties of Industrial Materials. 11th Edition. Wiley-Interscience, Wiley & Sons, Inc. Hoboken, NJ. 2004., p. 3463

  • LD50 Rat dermal >2000 mg/kg

    Hazardous Substances Data Bank (HSDB)Toxikologische Bewertung. Heidelberg, Berufsgenossenschaft der chemischen Industrie 259 38 p (2000)

As published

Quoted verbatim from the database named after each passage, never summarized — a summary of a toxicology statement is a new claim.

Toxicity Summary

  • The CIR Expert panel concludes Sodium p-Chloro-m-Cresol, p-Chloro-m-Cresol, Chlorothymol, m-Cresol, o-Cresol, Isopropyl Cresols, Thymol, o-Cymen-5-ol, Cavacrol are safe at concentrations up to 0.5% in cosmetics; however, the available data are insufficient to support the safety of p-Cresol and Mixed Cresols for use in cosmetic products.

    Cosmetic Ingredient Review (CIR)International Journal of Toxicology 25(Suppl. 1):29-127, 2006

  • Safe for use in cosmetics, with qualifications

    Cosmetic Ingredient Review (CIR)International Journal of Toxicology 25(Suppl. 1):29-127, 2006

  • IDENTIFICATION AND USE: Thymol forms colorless crystals, often large, or white crystalline powder. It is used as a pesticide (insecticide, fungicide, rodenticide, antimicrobial); also used in perfumery; as a mold and mildew preventive; in microscopy; as a preservative; antioxidant; flavoring; and lab reagent. Thymol is included in an FDA over-the-counter drug used as an antibacterial and antifungal agent, and approve…

    Hazardous Substances Data Bank (HSDB)

Human Toxicity Excerpts

  • /SIGNS AND SYMPTOMS/ In humans, thymol on its own or as an ingredient in combination preparations, considering its wide use, has led to primary skin irritation and skin sensitisation only in rare cases.

    Hazardous Substances Data Bank (HSDB)Toxikologische Bewertung. Heidelberg, Berufsgenossenschaft der chemischen Industrie 259 38 p (2000)

  • /SIGNS AND SYMPTOMS/ ... Mild local irritant. Resembles phenol in its systemic actions but less toxic, partly because it is less sol. ... Produces gastric pain, nausea, vomiting, central hyperactivity (eg, talkativeness), occasionally convulsions, coma, cardiac & respiratory collapse.

    Hazardous Substances Data Bank (HSDB)Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. II-189

  • /SIGNS AND SYMPTOMS/ Believed to lie near borderline between toxicity classes 3 & 4 /moderately & very toxic/.

    Hazardous Substances Data Bank (HSDB)Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. II-189

  • /GENOTOXICITY/ ...The genotoxic effects were evaluated in the human colon carcinoma cell line Caco-2, and the standard comet assay revealed that neither carvacrol (0-460 uM) nor thymol (0-250 uM) had any effects at 24 and 48 hr. The FPG-modified comet assay showed that the highest concentration of carvacrol (460 uM) caused DNA damage, indicating damage to the purine bases. These results should be used to identify the…

    Hazardous Substances Data Bank (HSDB)PMID 25038394LLana-Ruiz-Cabello M et al; Food Chem Toxicol. 72: 122-8 (2014)

  • For more Human Toxicity Excerpts (Complete) data for THYMOL (7 total), please visit the HSDB record page.

    Hazardous Substances Data Bank (HSDB)

Published passages via PubChem toxicology sections, aggregating Hazardous Substances Data Bank (HSDB), RTECS, LiverTox. No figure on this page is scored, ranked or combined into a risk level.

VIII · Evidence

Every measurement

One row per published value. The identifier in the last column resolves to the ChEMBL assay record it was read from.

Equilibrium binding constants 1

Ki and Kd — a concentration at equilibrium. Directly comparable across rows at the same target.

TargetClassTypeValue (nM)pXOrganismAssay
UncheckedUnclassifiedKi8,2005.09— organism not recordedCHEMBL964474

Functional readouts 2

IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.

TargetClassTypeValue (nM)pXOrganismAssay
Transient receptor potential cation channel subfamily A member 1Ion channelsEC5062,5004.20Homo sapiensCHEMBL1118242
Transient receptor potential cation channel subfamily A member 1Ion channelsEC5086,9004.06Homo sapiensCHEMBL4677023
P
PubChem
C
ChEMBL
R
Computed here with RDKit
D
Derived here from the stored measurement

IX · Trials

Registered clinical trials

Studies filed with ClinicalTrials.gov that name this compound as an intervention. A registered trial is a protocol, not a result — status and enrollment are printed beside every row, and withdrawn studies are counted rather than hidden.

6T

Registered studies

0T

Open or ongoing

6T

With a phase recorded

By phase

A study may carry two phase codes at once, so these count studies bearing each phase and do not sum to the total.

  • Phase 21
  • Phase 41
  • Not applicable4

By status

The registry’s own status for each record. Withdrawn and terminated studies are counted here rather than hidden — a stopped trial is part of what is known.

  • Unknown status3
  • Completed2
  • Withdrawn1

Every matched study

Newest first by start date. Each identifier opens the registry record it came from; the title is the sponsor’s own, quoted.

  • NCT07339670Completed · Not applicable

    Study of Gum Tissue Proteins in Smokers vs. Non-smokers After Cleaning

    Enrollment
    36Tactual
    Started
    2024-11-11
    Sponsor
    Al-Azhar University

    Conditions Smoking ( Cigarette) · Periodontitis Stage II

    Matched “Thymol” in the study’s intervention “Non Surgical Periodontal Treatment includes post operative mouth wash with Listerine® (ethanol 21.6%, methyl salicylate 0.06%, menthol 0.042%, thymol 0.064% and eucalyptol 0.092%)”

  • NCT06772506Completed · Not applicable

    Minimally Invasive Non-surgical Therapy for the Treatment of Splinted Stage IV Periodontitis

    Enrollment
    40Tactual
    Started
    2022-08-11
    Sponsor
    Minia University

    Conditions Periodontitis · Stage IV Periodontitis · Minimally Invasive Treatment · Splints

    Matched “Thymol” in the study’s intervention “Non Surgical Periodontal Treatment includes post operative mouth wash with Listerine® (ethanol 21.6%, methyl salicylate 0.06%, menthol 0.042%, thymol 0.064% and eucalyptol 0.092%)”

  • NCT05427721Unknown status · Phase 2

    Thymol on Netrin-1 on Obese Patients

    Enrollment
    30Testimated
    Started
    2022-04-01
    Sponsor
    Centro Universitario de Ciencias de la Salud, Mexico

    Conditions Inflammatory Response · Obesity

    Matched “Thymol” in the study’s intervention “Thymol”

  • NCT03767504Unknown status · Not applicable

    A Study to Evaluate the Effect and Tolerance of Musclin™ (Thymol) in Healthy Subjects

    Enrollment
    20Testimated
    Started
    2018-11-13
    Sponsor
    Innovus Pharmaceuticals, Inc.

    Conditions Healthy Volunteers

    Matched “Thymol” in the study’s intervention “Thymol”

  • NCT02202304Withdrawn · Phase 4

    The Effects of Chlorhexidine/Thymol Varnish on Partial Denture Patient

    Enrollment
    0Tactual
    Started
    2017-09-10
    Sponsor
    Rosa Moreno Lopez

    Conditions Periodontal Disease · Caries

    Matched “Thymol” in the study’s intervention “Chlorhexidine/Thymol varnish”

  • NCT02874963Unknown status · Not applicable

    FM-SRP and Tooth Extraction Improve Type 2 Diabetes Mellitus in Periodontitis

    Enrollment
    160Testimated
    Started
    2015-11
    Sponsor
    University Clinical Centre of Kosova

    Conditions Periodontitis · Type 2 Diabetes Mellitus

    Matched “Thymol” in the study’s intervention “Non Surgical Periodontal Treatment includes post operative mouth wash with Listerine® (ethanol 21.6%, methyl salicylate 0.06%, menthol 0.042%, thymol 0.064% and eucalyptol 0.092%)”

Records from ClinicalTrials.gov (U.S. National Library of Medicine, NIH), API v2. A study is listed against a compound only when a verified name for that compound appears as a whole word in one of the study's own intervention names. A short code must appear as written, and a name the registry uses for something else (Aleph, a vaccine maker) is not matched. Title matches are not accepted. The matched name and the intervention text it matched are shown with every row.

Searched as Thymol · 2-Isopropyl-5-methylphenol · 5-Methyl-2-(1-methylethyl)phenol. Run this search at the registry — it returns the unfiltered result, including studies this page rejected as belonging to a different molecule.

A registered trial is a protocol somebody filed with the registry. It is not a result, and nothing on this plate says whether Thymol worked.

XI · Literature

Sources behind this dossier

The papers this compound's values were read from, ranked by what each contributed. Not a review of the field.

Every paper below is one some value on this page came from — a binding constant, a passage of pharmacology or toxicology, or a measured duration. Each entry says what this archive took from it. Nothing else is claimed about any of them: the title is the study’s own account of itself, and a summary written here would be an assertion with no source behind it.

  1. 01

    Evaluation of the mutagenicity and genotoxic potential of carvacrol and thymol using the Ames Salmonella test and alkaline, Endo III- and FPG-modified comet assays with the human cell line Caco-2

    LLana-Ruiz-Cabello M, Maisanaba S, Puerto M et al. · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2014

    • · Human Toxicity Excerpts

    PMID 25038394

  2. 02

    Potentiation of macrophage activity by thymol through augmenting phagocytosis

    Chauhan AK, Jakhar R, Paul S et al. · International immunopharmacology 2014

    • · Mechanism of Action

    PMID 24316253