2C-T-7
PubChem records this structure as 2,5-Dimethoxy-4-(n)-propylthiophenethylamine.
Also known asBlue Mystic · 2C-T7 · Tweety-Bird Mescaline
2-(2,5-dimethoxy-4-propylsulfanylphenyl)ethanamine
- PubChem CID
- 24728635
- ChEMBL
- CHEMBL126432
- Measurements
- 0
- InChIKey
- OLEVEPDJOFPJTF-UHFFFAOYSA-N
I · Summary
What is known
Published passages, each quoted whole and attributed to the database that published it. Two blocks are written here rather than quoted, and both say so where they stand: the synthesized summary at the top, which may draw only on the passages beneath it, and the history note, which cites the works it came from. Every claim in either carries a marker to its source.
What it is
2,5-dimethoxy-4-(n)-propylthiophenethylamine is a DEA Schedule I controlled substance. Substances in the DEA Schedule I have no currently accepted medical use in the United States, a lack of accepted safety for use under medical supervision, and a high potential for abuse. It is a Hallucinogenic substances substance.
Recognized use
2C-T-7 is illegal. In March 2004 the Drug Enforcement Administration designated 2C-T-7 as a Schedule I substance under the Controlled Substances Act. Schedule I drugs ... have a high potential for abuse, serve no legitimate medical use in treatment in the United States, and have a lack of accepted medical safety for use under medical supervision.
Hazardous Substances Data Bank (HSDB)USDOJ/NDIC; 2C-T-7 Fast Facts (November 2004). NDIC Product No. 2004-L0559-008. Available from, as of April 02, 2008: https://www.usdoj.gov/ndic/pubs11/12207/index.htm#Top
2C-T-7 is a synthetic drug that produces hallucinogenic effects. ... 2C-T-7 /belongs to/ Schedule I Controlled Substances.
Hazardous Substances Data Bank (HSDB)USDOJ/NDIC; 2C-T-7 Fast Facts (November 2004). NDIC Product No. 2004-L0559-008. Available from, as of April 02, 2008: https://www.usdoj.gov/ndic/pubs11/12207/index.htm#Top
2C-T-7 is abused orally and intranasally for its hallucinogenic effects. 2C-T-7 is not approved for marketing by the Food and Drug Administration and is not sold legally in the United States.
Hazardous Substances Data Bank (HSDB)U.S. Department of Justice, Drug Enforcement Administration, Office of Diversion Control; Drugs and Chemicals of Concern: 2,5-Dimethoxy-4-(n)-propylthiophenethylamine. Available from, as of January 6, 2008: https://www.deadiversion.usdoj.gov/drugs_concern/2ct7.htm
How it acts
Studies involving a bromine-substituted analogue, 2C-B (4-bromo-2,5- dimethoxyphenethylamine), have shown it to be a partial agonist for 5-HT2 (5-HT2A and 5-HT2C) serotonergic receptors and 1-adrenergic receptors. At 10-6 M, 2C-B also acted as a competitive 5-HT antagonist, but, at higher concentrations (2.8 x 10-5M), it acted as a non-competitive 5-HT antagonist. ... As 2C-T-7 is phenethylamine based, it is possible that it may have serotonergic receptor affinity similar to 2C-B (i.e. binding to 5-HT2 and, to some degree, 5-HT1 receptors).
Hazardous Substances Data Bank (HSDB)European Monitoring Center for Drugs and Drug Addiction (EMCDDA); Risk Assessments - Report on the risk assessment of 2C-I, 2C-T-2 and 2C-T-7 in the framework of the joint action on new synthetic drugs. p 47(2004). ISBN: 92-9168-181-4
The subjective effects of 2C-T-7, like those of 2C-B and DOM, appear to be mediated through central serotonin receptors. 2C-T-7 selectively binds to the 5-HT receptor system.
Hazardous Substances Data Bank (HSDB)USDOJ/DEA Office of Diversion Control; Drugs and Chemicals of Concern on 2,5-Dimethoxy-4-(n)-propylthiophenethylamine (2C-T-7) (August 2007). Available from, as of April 02, 2008: https://www.deadiversion.usdoj.gov/drugs_concern/index.html
Behavior carries the pharmacological classes and the acute-effect durations, with plasma half-life kept separate from duration of effect.
In the body
... the primary route of administration is oral. However, insufflation (snorting) is also commonly mentioned in user reports. Some less common routes of administration include smoking, rectal administration and intravenous or intramuscular administration.
Absorption, Distribution and Excretion
Hazardous Substances Data Bank (HSDB)European Monitoring Center for Drugs and Drug Addiction (EMCDDA); Risk Assessments - Report on the risk assessment of 2C-I, 2C-T-2 and 2C-T-7 in the framework of the joint action on new synthetic drugs. p 46 (2004). ISBN: 92-9168-181-4
... it is likely that its metabolism may proceed via similar pathways as 2C-B, possibly with additional metabolic reactions.
Metabolism/Metabolites
Hazardous Substances Data Bank (HSDB)European Monitoring Center for Drugs and Drug Addiction (EMCDDA); Risk Assessments - Report on the risk assessment of 2C-I, 2C-T-2 and 2C-T-7 in the framework of the joint action on new synthetic drugs. p 48 (2004). ISBN: 92-9168-181-4
The phenethylamine-derived designer drug 4-ethyl-2,5-dimethoxy-beta-phenethylamine (2C-E) was found to be mainly metabolized in rats by O-demethylation, N-acetylation, hydroxylation of the ethyl side chain at C2' or at C1' followed by oxidation at C1' to the corresponding ketone, by deamination followed by reduction to the corresponding alcohols or by oxidation to the corresponding acids, and finally combinations of these steps. Most of the metabolites were excreted in conjugated form. The authors' systematic toxicological analysis (STA) procedure using full-scan GC-MS allowed the detection of an intake of a dose of 2C-E in rat urine that corresponds to a common drug users' dose. Assuming si…
Metabolism/Metabolites
Hazardous Substances Data Bank (HSDB)PMID 16600701Theobald DS, Maurer HH; J Chromatogr B Analyt Technol Biomed Life Sci 842 (2): 76-90 (2006)
The in vivo metabolism of 2,5-dimethoxy-4-propylthiophenethylamine (2C-T-7), a ring-substituted psychoactive phenethylamine, was studied in rat. Male Wistar rats were administered 10 mg/kg 2C-T-7 hydrochloride orally, and 24-hr urine fractions were collected. After enzymatic hydrolysis of the urine sample, the metabolites were extracted by liquid-liquid extraction and analyzed by liquid chromatography/mass spectrometry. 2C-T-7-sulfoxide, N-acetyl-2C-T-7-sulfoxide, N-acetyl-2,5-dimethoxy-4-methylthiophenethylamine-sulfoxide, N-acetyl-2,5-dimethoxy-4-(2-hydroxypropylthio)phenethylamine-sulfoxide, and N-acetyl-2,5-dimethoxy-4-(2-hydroxypropylthio)phenethylamine-sulfone were detected as the prim…
Metabolism/Metabolites
Hazardous Substances Data Bank (HSDB)PMID 17614010Kanamori T et al; Xenobiotica 37 (6): 679-92 (2007)
Studies are described on the metabolism and the toxicological analysis of the phenethylamine-derived designer drug 2,5-dimethoxy-4-ethylthio-beta-phenethylamine (2C-T-2) in rat urine using gas chromatography/mass spectrometry (GC/MS) after enzymatic cleavage of conjugates, liquid-liquid extraction and derivatization. The structures of 14 metabolites were assigned tentatively by detailed interpretation of their mass spectra. Identification of these metabolites indicated that 2C-T-2 was metabolized by sulfoxidation followed by N-acetylation and either hydroxylation of the S-ethyl side chain or demethylation of one methoxy group, O-demethylation of the parent compound followed by N-acetylation…
Metabolism/Metabolites
Hazardous Substances Data Bank (HSDB)PMID 16041763Theobald DS et al; J Mass Spectrom 40 (9): 1157-72 (2005)
History, discovery and cultural use
— Not in this archive. PubChem, ChEMBL and the Human Protein Atlas publish pharmacology, regulation and toxicology, and none of them publishes a heading for when 2C-T-7 was first made, by whom, or how it has been used. That is a gap in the databases this site reads and not a gap in the literature — the history of these compounds is written, at length and under peer review, in the works below. This site does not summarize them; it says where they are. Where a published passage above happens to touch origin or traditional use, it appears inside the entry that carries it.
Histories of this field
Scholarship on psychedelics generally, not on 2C-T-7 specifically. Whether any of these treats this compound is a question for the book, not for this page.
Mescaline: A Global History of the First Psychedelic
Traces mescaline and the peyote and San Pedro cacti from pre-Columbian ritual use through nineteenth-century chemistry to twentieth-century psychiatry and the counterculture.
Jay M. Mescaline: A Global History of the First Psychedelic. Yale University Press, New Haven and London; 2019. ISBN 9780300231076.
Expanding Mindscapes: A Global History of Psychedelicsopen access
Essays on the international and cross-cultural history of psychedelic science, deliberately decentring the standard North American and European account.
Dyck E, Elcock C, editors. Expanding Mindscapes: A Global History of Psychedelics. The MIT Press, Cambridge MA; 2023. ISBN 9780262546935 (paper), 9780262376891 (open access). doi:10.7551/mitpress/14417.001.0001.
Plants of the Gods: Their Sacred, Healing, and Hallucinogenic Powers
Botany, ethnography and chemistry of the principal hallucinogenic plants, by the founder of modern ethnobotany and the chemist who first synthesized LSD.
Schultes RE, Hofmann A, Rätsch C. Plants of the Gods: Their Sacred, Healing, and Hallucinogenic Powers. 2nd ed. Healing Arts Press, Rochester VT; 2001. ISBN 9780892819799.
Psychonauts: Drugs and the Making of the Modern Mind
The tradition of scientific self-experimentation with psychoactive drugs, and its part in the emergence of psychology and of modernism.
Jay M. Psychonauts: Drugs and the Making of the Modern Mind. Yale University Press, New Haven; 2023. ISBN 9780300257946.
Ancient Psychoactive Substances
Archaeological and bioarchaeological evidence for psychoactive plant use across the ancient world.
Fitzpatrick SM, editor. Ancient Psychoactive Substances. University Press of Florida, Gainesville; 2018. ISBN 9780813056708.
A chapter tracing psychedelic and entactogen research from earlier ritual use through the mid-century research period to current clinical trials.
Stroud C, Posey Norris SM, Matney C, editors. History and Current Status of Psychedelics and Entactogens for the Treatment of Psychiatric Disorders. In: Exploring Psychedelics and Entactogens as Treatments for Psychiatric Disorders: Proceedings of a Workshop. National Academies Press, Washington DC; 2022. NBK587225.
Workshop proceedings record what participants said; they are not a consensus statement of the National Academies.
Peer-reviewed review covering the isolation, synthesis, pharmacology and ritual use of peyote and mescaline.
Dinis-Oliveira RJ, Pereira CL, da Silva DD. Pharmacokinetic and Pharmacodynamic Aspects of Peyote and Mescaline: Clinical and Forensic Repercussions. Current Molecular Pharmacology 12(3):184–194; 2019. doi:10.2174/1874467211666181010154139.
Institutional archives
- Heffter Research Institute Funds and coordinates clinical research on psilocybin, and keeps records of the studies it has supported since 1993. Sponsors the research it archives.
- Multidisciplinary Association for Psychedelic Studies (MAPS) Sponsors clinical research, chiefly on MDMA-assisted therapy, and publishes an archive of historical and contemporary documents. A sponsor and an advocacy organization, not a disinterested archive; its clinical programme has a commercial arm.
The rest of this dossier
- Toxicology — 5 published passages, plus any assay in this archive bearing on toxicity.
- Legal — DEA Schedule I, with the passage it was read from.
Passages via PubChem descriptive sections, aggregating DrugBank, LiverTox, FDA, DEA, HSDB, EPA. Each is quoted whole and attributed to the database that published it. The only prose written here about 2C-T-7 is the history note, which says so on its face and carries a reference for every claim in it.
II · Identity
Structure and descriptors
Descriptors are computed here with RDKit from the structure PubChem returns — not from the archive's stored copy, so an edited local structure cannot reach this table.
- Formula
- C13H21NO2SR
- Molecular weight
- 255.38g/molR
- Exact mass
- 255.1293DaR
- cLogP
- 2.71R
- TPSA
- 44.5ŲR
- H-bond donors
- 1R
- H-bond acceptors
- 4R
- Rotatable bonds
- 7R
- Aromatic rings
- 1R
- Heavy atoms
- 17R
- Fraction sp³
- 0.538R
- Formal charge
- 0R
Computed with RDKit 2025.09.2 from the SMILES returned by PubChem. Audit run 26/09/2026.
Bemis–Murcko scaffold
c1ccccc1
Shared with 2-Bromomescaline, 2-TOET, 2-TOM, 2,3,4,5-Tetramethoxyamphetamine, 2,4-dimethoxyamphetamine, 2,5-Dimethoxy-4-(2-fluoroethyl)amphetamine and 129 more. All families
III · Behavior
Behavioral summary
Class, mechanism, and the duration of acute effects — each quoted from the record or trial that publishes it. Duration of effects and plasma half-life are shown separately, because they are different quantities and diverge by a factor of three or four.
Classification
MeSH indexes no pharmacological class for this compound.
Duration of acute subjective effects
—
No controlled human trial reporting a duration for this compound is cited here. The archive does hold onset and duration ranges for it, inherited from an earlier build, but their source column is empty and so they cannot be shown. A duration is not inferred from a chemical relative.
Plasma elimination half-life
How fast the body clears the drug — not how long the effects last. The two diverge sharply: LSD is cleared with a half-life of about 2.6 h while its subjective effects run 8–12 h.
No half-life is published for this compound in the sources this site reads.
Primary pharmacological drivers
ChEMBL holds no curated mechanism-of-action record for this compound. The measured affinities below are the evidence this archive has for what it binds.
Mechanism, as published
Quoted verbatim from the database named after each passage, never summarized.
Studies involving a bromine-substituted analogue, 2C-B (4-bromo-2,5- dimethoxyphenethylamine), have shown it to be a partial agonist for 5-HT2 (5-HT2A and 5-HT2C) serotonergic receptors and 1-adrenergic receptors. At 10-6 M, 2C-B also acted as a competitive 5-HT antagonist, but, at higher concentrations (2.8 x 10-5M), it acted as a non-co…
Hazardous Substances Data Bank (HSDB)European Monitoring Center for Drugs and Drug Addiction (EMCDDA); Risk Assessments - Report on the risk assessment of 2C-I, 2C-T-2 and 2C-T-7 in the framework of the joint action on new synthetic drugs. p 47(2004). ISBN: 92-9168-181-4 The subjective effects of 2C-T-7, like those of 2C-B and DOM, appear to be mediated through central serotonin receptors. 2C-T-7 selectively binds to the 5-HT receptor system.
Hazardous Substances Data Bank (HSDB)USDOJ/DEA Office of Diversion Control; Drugs and Chemicals of Concern on 2,5-Dimethoxy-4-(n)-propylthiophenethylamine (2C-T-7) (August 2007). Available from, as of April 02, 2008: https://www.deadiversion.usdoj.gov/drugs_concern/index.html
IV · Clinical
Clinical description
Where this compound's substance class sits in ICD-11 and DSM-5-TR, and how much of the recorded literature speaks to each domain of a mental status examination.
No diagnostic chapter is shown for this compound. Either PubChem records no MeSH pharmacological class for it, or the class it records is not one of the substance classes ICD-11 gives a chapter to. Inferring a chapter from the compound’s name or its binding profile would be a diagnosis this archive is in no position to make.
How much has been written about each domain
The clinical domains, and how many of the records this archive holds for this compound say something under each. What the terms mean, and the word list behind every spoke, are set out in the method.
- Mood 1
- matched on “irritab” · in Toxicology: Hazardous Substances Data Bank (HSDB)
- Perception 1
- matched on “hallucinat” · in Toxicology: Hazardous Substances Data Bank (HSDB)
- Cognition 2
- matched on “concentrat”, “confus”, “memory” · in Pharmacology: Mechanism of Action; Toxicology: Hazardous Substances Data Bank (HSDB)
- Psychomotor activity 1
- matched on “restless” · in Toxicology: Hazardous Substances Data Bank (HSDB)
- Insight and judgment 1
- matched on “judgment” · in Toxicology: Hazardous Substances Data Bank (HSDB)
VI · Profile
Affinity rosette
No measurement for 2C-T-7 converts to an affinity at a molecular target, so there is no rosette to draw. This is an absence of data, not a finding about the compound.
VII · Toxicology
Toxicological profile
What has been measured, and what has been published — kept apart, and neither scored. There is no risk rating on this page; the archive once carried one, identical for every compound, produced by a stub.
Measured in this archive
Assays that bear on toxicity, drawn from the same ChEMBL records as everything else on this page. They are measurements of what a compound binds or does to cells — not verdicts about what it does to a person.
No hERG, cytochrome, cytotoxicity or transport measurement exists for 2C-T-7 in this archive.
As published
Quoted verbatim from the database named after each passage, never summarized — a summary of a toxicology statement is a new claim.
Human Toxicity Excerpts
/SIGNS AND SYMPTOMS/ 2C-T-7 produces negative physical and psychological effects in users. Physical effects include visual and auditory disturbances and distortions, increased blood pressure, blurred vision, dehydration, dilated pupils, headaches, irregular heartbeat, jaw clenching, nausea, and vomiting. Psychological effects associated with the use of 2C-T-7 include emotional distress, hallucinations, inability to s…
Hazardous Substances Data Bank (HSDB)USDOJ/NDIC; 2C-T-7 Fast Facts (November 2004). NDIC Product No. 2004-L0559-008. Available from, as of April 02, 2008: https://www.usdoj.gov/ndic/pubs11/12207/index.htm#Top
/SIGNS AND SYMPTOMS/ 2C-T-7 abuse has been associated with convulsions in humans.
Hazardous Substances Data Bank (HSDB)USDOJ/DEA Office of Diversion Control; Drugs and Chemicals of Concern on 2,5-Dimethoxy-4-(n)-propylthiophenethylamine (2C-T-7) (August 2007). Available from, as of April 02, 2008: https://www.deadiversion.usdoj.gov/drugs_concern/index.html
/SIGNS AND SYMPTOMS/ Subjective evidence from user surveys indicates variable observations regarding cardiovascular and thermoregulatory responses. The tachycardia and/or headaches reported by a number of users were thought to indicate the possibility of increased blood pressure. However, the value of such reports is seriously limited by the lack of medical confirmation and the inconsistency of observations regarding…
Hazardous Substances Data Bank (HSDB)European Monitoring Center for Drugs and Drug Addiction (EMCDDA); Risk Assessments - Report on the risk assessment of 2C-I, 2C-T-2 and 2C-T-7 in the framework of the joint action on new synthetic drugs. p 47-48 (2004). ISBN: 92-9168-181-4
/SIGNS AND SYMPTOMS/ According to user self-reports, 2C-T-7 use involving intranasal administration appeared to result in a greater number of references to adverse effects than with oral administration. The most common side-effect was nausea, followed by headaches, vomiting, tachycardia, dehydration, diarrhea, hypertension and, to a lesser degree, gastrointestinal effects, confusion or delirium (at high doses), dizzi…
Hazardous Substances Data Bank (HSDB)European Monitoring Center for Drugs and Drug Addiction (EMCDDA); Risk Assessments - Report on the risk assessment of 2C-I, 2C-T-2 and 2C-T-7 in the framework of the joint action on new synthetic drugs. p 48-50 (2004). ISBN: 92-9168-181-4
For more Human Toxicity Excerpts (Complete) data for 2,5-DIMETHOXY-4-(N)-PROPYLTHIOPHENETHYLAMINE (7 total), please visit the HSDB record page.
Published passages via PubChem toxicology sections, aggregating Hazardous Substances Data Bank (HSDB), RTECS, LiverTox. No figure on this page is scored, ranked or combined into a risk level.
VIII · Evidence
Every measurement
One row per published value. The identifier in the last column resolves to the ChEMBL assay record it was read from.
No bioactivity measurement is recorded for this compound in the archive.
- P
- PubChem
- C
- ChEMBL
- R
- Computed here with RDKit
- D
- Derived here from the stored measurement
IX · Trials
Registered clinical trials
Studies filed with ClinicalTrials.gov that name this compound as an intervention. A registered trial is a protocol, not a result — status and enrollment are printed beside every row, and withdrawn studies are counted rather than hidden.
— No registered study names 2C-T-7 as an intervention. That is an absence of registered research, not evidence about the compound. Most of this archive has never been the subject of a registered trial.
Records from ClinicalTrials.gov (U.S. National Library of Medicine, NIH), API v2. A study is listed against a compound only when a verified name for that compound appears as a whole word in one of the study's own intervention names. A short code must appear as written, and a name the registry uses for something else (Aleph, a vaccine maker) is not matched. Title matches are not accepted. The matched name and the intervention text it matched are shown with every row.
Searched as 2C-T-7 · Blue Mystic · Tweety-Bird Mescaline. Run this search at the registry.
A registered trial is a protocol somebody filed with the registry. It is not a result, and nothing on this plate says whether 2C-T-7 worked.
X · Legal
Controlled-substance status
United States federal scheduling, read from the DEA records this archive holds and shown with the passage each was read from. Not legal advice, and not necessarily current.
- DEA class
- Phenethylamines (2C Series) (H)
- Added
- July 2006
As the DEA states it
Quoted whole. The badge above is a reading of these passages and adds nothing to them.
2C-T-7 (Class: Phenethylamines (2C Series) (H), Added Date: 07-2006)
Schedule I - Substances in the DEA Schedule I have no currently accepted medical use in the United States, a lack of accepted safety for use under medical supervision, and a high potential for abuse.
Other regulatory records
Registers outside the DEA that hold an entry for 2C-T-7 — chemical-safety and national inventories, each naming itself. They are not scheduling decisions.
Schedules of controlled substances are established by section 202 of the Controlled Substances Act (21 U.S.C. 812). Unless specifically excepted or unless listed in another schedule, any material, compound, mixture, or preparation, which contains any quantity of the following hallucinogenic substances, or which contains any of its salts, isomers, and salts of isomers whenever the existence of such salts, isomers, and salts of isomers is possible within the specific chemical designation (for purposes of this paragraph only, the term "isomer" includes the optical, position and geometric isomers). 2,5-Dimethoxy-4-(n)-propylthiophenethylamine is included on this list.; DEA Code #7348; Drug clas…
Hazardous Substances Data Bank (HSDB)21 CFR 1308.11(d); U.S. National Archives and Records Administration's Electronic Code of Federal Regulations. Available from, as of November 12, 2007: https://www.ecfr.gov
United States federal status only. State law differs, and so does the law of every other country — none of it is represented here. Scheduling changes, and this reflects the DEA records held by PubChem descriptive sections when the monograph was last harvested, not necessarily today. This is a record of what a database publishes, not legal advice.
XI · Literature
Sources behind this dossier
The papers this compound's values were read from, ranked by what each contributed. Not a review of the field.
No reference is recorded against any value for this compound. Its measurements come from ChEMBL assay records that carry an assay identifier but no publication, so there is no paper to cite here — an absence in the upstream record, not a judgment about the evidence. The assay identifiers in Every measurement resolve to the records the values were read from.